Longitudinal follow-up of body composition in hematopoietic stem cell transplant patients.

Détails

ID Serval
serval:BIB_B55707795673
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Longitudinal follow-up of body composition in hematopoietic stem cell transplant patients.
Périodique
Bone Marrow Transplantation
Auteur⸱e⸱s
Kyle U.G., Chalandon Y., Miralbell R., Karsegard V.L., Hans D., Trombetti A., Rizzoli R., Helg C., Pichard C.
ISSN
0268-3369
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
35
Numéro
12
Pages
1171-1177
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
Patients with hematological malignancies are well nourished prior to allogeneic hematopoietic stem cell transplantation (HSCT). HSCT and associated complications can affect body composition. The study evaluated cross-sectionally the prevalence and longitudinally the changes in lean body mass index (LBMI) in HSCT patients. Patients (n=82) were classified as normal or low LBMI. Logistic regression analyses were used to estimate odds ratios (OR) for low vs normal LBMI, between healthy volunteers and patients; for limited or extensive vs no chronic graft-versus-host-disease (GVHD); and for decreased (Karnofsky <80) vs normal functional status (>80). Patients were significantly more likely to have low LBMI at 6, 12 months, 2-3, 4-6 and >6 years than volunteers. In all, 38% of patients were below pre-HSCT LBMI at 4-6 years post-HSCT. Low LBMI was significantly associated with steroid treatment (OR 2.6, confidence intervals (CI) 1.3-5.2, P=0.008); limited (OR 5.5, CI 1.7-18.5, P=0.005) or extensive chronic GVHD (OR 20.3, CI 5.7-71.6, P<0.001); and decreased performance status (Karnofsky scores of < or =80) (OR 2.7, CI 1.3-5.9, P=0.01). Patients were more likely to have low LBMI than volunteers. Chronic GVHD and low performance status were associated with low LBMI; thus, complications and/or treatment increase the likelihood of low LBMI.
Mots-clé
Body Composition, Bone Marrow Transplantation, Case-Control Studies, Graft vs Host Disease, Hematologic Neoplasms, Hematopoietic Stem Cell Transplantation, Humans, Karnofsky Performance Status, Longitudinal Studies, Odds Ratio, Retrospective Studies, Steroids, Transplantation, Homologous
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/03/2009 12:33
Dernière modification de la notice
20/08/2019 15:23
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