n-3 polyunsaturated fatty acid intake and cancer risk in Italy and Switzerland

Détails

ID Serval
serval:BIB_B5098CA22D1C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
n-3 polyunsaturated fatty acid intake and cancer risk in Italy and Switzerland
Périodique
International Journal of Cancer
Auteur⸱e⸱s
Tavani  Alessandra, Pelucchi  Claudio, Parpinel  Maria, Negri  Eva, Franceschi  Silvia, Levi  Fabio, La Vecchia  Carlo
ISSN
0020-7136
Statut éditorial
Publié
Date de publication
2003
Volume
105
Numéro
1
Pages
113-116
Notes
Réf. IUMSP: R 03/15
SAPHIRID:44982
Résumé
Data from a series of case-control studies, conducted in Italy and Switzerland between 1991 and 2001, have been analyzed to evaluate the role of n-3 polyunsaturated fatty acid (PUFA) intake in the etiology of cancer of oral cavity and pharynx (736 cases, 1772 controls), esophagus (395 cases, 1066 controls), large bowel (1394 colon, 886 rectum, 4765 controls), breast (2900 cases, 3122 controls) and ovary (1031 cases, 2411 controls). Controls were patients admitted to hospital for acute, non-neoplastic conditions, unrelated to modifications in diet. The multivariate odds ratios (OR) for the highest quintile of n-3 PUFAs compared to the lowest one were 0.5 for oral and pharyngeal cancer, 0.5 for oesophageal cancer, 0.7 for colon cancer, 0.8 for rectal and breast cancer and 0.6 for ovarian cancer; the estimates and the trends in risk were significant for all cancer sites, excluding rectal and breast cancer. The estimates for an increase in n-3 PUFAs of 1 g/week were 0.70 for oral and pharyngeal cancer, 0.71 for oesophageal, 0.88 for colon, 0.91 for rectal, 0.90 for breast and 0.85 for ovarian cancer. All the estimates were statistically significant, excluding that for rectal cancer, and consistent across strata of age and gender. These results suggest that n-3 PUFAs decrease the risk of several cancers.
Pubmed
Web of science
Création de la notice
06/03/2008 15:31
Dernière modification de la notice
20/08/2019 15:23
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