The puzzles of the prokineticin 2 pathway in human reproduction.

Détails

ID Serval
serval:BIB_B5091A09A63B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The puzzles of the prokineticin 2 pathway in human reproduction.
Périodique
Molecular and Cellular Endocrinology
Auteur(s)
Balasubramanian R., Plummer L., Sidis Y., Pitteloud N., Martin C., Zhou Q.Y., Crowley W.F.
ISSN
1872-8057 (Electronic)
ISSN-L
0303-7207
Statut éditorial
Publié
Date de publication
2011
Volume
346
Numéro
1-2
Pages
44-50
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., ExtramuralPublication Status: ppublish
Résumé
Prokineticin, 1 (PROK1) and prokineticin 2 (PROK2), are two closely related proteins that were identified as the mammalian homologs of their two amphibian homologs, mamba intestinal toxin (MIT-1) and Bv8. MIT-1 was initially identified as a non-toxic constituent in the venom of the black mamba snake (Dendroaspis polylepis) (Joubert and Strydom, 1980) while Bv8 was identified in the skin secretion of the toad, Bombina variegate (Mollay et al., 1999). All three homologs stimulate gastrointestinal motility thus accounting for their family name "prokineticins" (Schweitz et al., 1990, 1999). However, since its initial description, both PROK1 and PROK2 have been found to regulate a dazzling array of biological functions throughout the body. In particular, PROK1 acts as a potent angiogenic mitogen on endocrine vascular epithelium, thus earning its other name, Endocrine gland-vascular endothelial factor (EG-VEGF) (LeCouter et al., 2002). In contrast, the PROK2 signaling pathway is a critical regulator of olfactory bulb morphogenesis and sexual maturation in mammals and this function is the focus of this review.
Pubmed
Web of science
Création de la notice
17/02/2012 10:35
Dernière modification de la notice
20/08/2019 15:23
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