Differential role of naïve and memory CD4 T-cell subsets in primary alloresponses.

Détails

ID Serval
serval:BIB_B4E2C3751E16
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Differential role of naïve and memory CD4 T-cell subsets in primary alloresponses.
Périodique
American Journal of Transplantation
Auteur(s)
Golshayan D., Wyss J.C., Buckland M., Hernandez-Fuentes M., Lechler R.I.
ISSN
1600-6143[electronic], 1600-6135[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
10
Numéro
8
Pages
1749-1759
Langue
anglais
Résumé
The T cell response to major histocompatibility complex (MHC) alloantigens occurs via two main pathways. The direct pathway involves the recognition of intact allogeneic MHC:peptide complexes on donor cells and provokes uniquely high frequencies of responsive T cells. The indirect response results from alloantigens being processed like any other protein antigen and presented as peptide by autologous antigen-presenting cells. The frequencies of T cells with indirect allospecificity are orders of magnitude lower and comparable to other peptide-specific responses. In this study, we explored the contributions of naïve and memory CD4(+) T cells to these two pathways. Using an adoptive transfer and skin transplantation model we found that naive and memory CD4(+) T cells, both naturally occurring and induced by sensitization with multiple third-party alloantigens, contributed equally to graft rejection when only the direct pathway was operative. In contrast, the indirect response was predominantly mediated by the naïve subset. Elimination of regulatory CD4(+)CD25(+) T cells enabled memory cells to reject grafts through the indirect pathway, but at a much slower tempo than for naïve cells. These findings have implications for better targeting of immunosuppression to inhibit immediate and later forms of alloimmunity.
Mots-clé
Allorecognition, indirect pathway, memory T cells, naive T cells, transplantation regulatory t-cells, versus-host-disease, disparate skin-grafts, mhc class-ii, in-vivo, transplantation tolerance, indirect recognition, allograft-rejection, monoclonal-antibody, cd4(+)
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/08/2010 15:25
Dernière modification de la notice
20/08/2019 15:23
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