Association between foot growth and musculoskeletal loading in children with Prader-Willi syndrome before and during growth hormone treatment

Détails

ID Serval
serval:BIB_B49B69D32786
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Association between foot growth and musculoskeletal loading in children with Prader-Willi syndrome before and during growth hormone treatment
Périodique
Journal of Pediatrics
Auteur(s)
Eiholzer Urs, Meinhardt Udo, Gallo Chiara, Schlumpf Michael, Rousson Valentin, L'Allemand Dagmar
ISSN
1097-6833[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
154
Numéro
2
Pages
225-229
Langue
anglais
Résumé
OBJECTIVE: To explore how foot growth relates to musculoskeletal loading in children with Prader-Willi syndrome (PWS). STUDY DESIGN: In 37 children with PWS, foot length (FL) before and after 6 years of growth hormone therapy (GHT) was retrospectively evaluated with parental and sibling's FL, height, and factors reflecting musculoskeletal loading, such as weight for height (WfH), lean body mass (LBM; dual energy X-ray absorptiometry, deuterium labeled water), physical activity (accellerometry), and walk age. Because of the typically biphasic evolution of body mass and the late walk age in PWS, 2 age groups were separated (group 1, >2.5 years; group 2, < or =2.5 years). RESULTS: Children with PWS normalized height, but not FL after 6 years of GHT. Parental FL correlation with PWS's FL was lower than with sibling's FL. In group 1, FL positively correlated with WfH, LBM, and physical activity. In group 2, FL negatively correlated with age at onset of independent ambulation. Foot catch-up growth with GHT was slower in group 2 compared with group 1. CONCLUSION: In PWS, FL is positively associated with musculoskeletal loading. Small feet in children with PWS before and during long-term GHT may be more than just another dysmorphic feature, but may possibly reflect decreased musculoskeletal loading influencing foot growth and genetic and endocrine factors.
Mots-clé
Adolescent, Body Height, Body Height/physiology, Body Mass Index, Body Weight, Body Weight/physiology, Child, Child, Preschool, Female, Foot, Foot/anatomy & histology, Foot/growth & development, Growth Hormone, Growth Hormone/therapeutic use, Humans, Male, Motor Activity, Prader-Willi Syndrome, Prader-Willi Syndrome/drug therapy, Prader-Willi Syndrome/physiopathology, Retrospective Studies, Walking, Walking/physiology, Weight-Bearing, Weight-Bearing/physiology
Pubmed
Web of science
Création de la notice
11/03/2009 10:14
Dernière modification de la notice
20/08/2019 15:23
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