Dynamic modulation of theta–gamma coupling during rapid eye movement sleep

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Ressource 1Télécharger: ThetaGammaREM_SLEEP.pdf (1050.76 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_B44FEB088DEC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Dynamic modulation of theta–gamma coupling during rapid eye movement sleep
Périodique
Sleep
Auteur⸱e⸱s
Bandarabadi Mojtaba, Richard Boyce, Carolina Gutierrez Herrera, Bassetti Claudio L, Sylvain Williams, Schindler Kaspar, Adamantidis Antoine
Statut éditorial
Publié
Date de publication
24/12/2019
Langue
anglais
Résumé
Theta phase modulates gamma amplitude in hippocampal networks during spatial navigation and rapid eye movement (REM) sleep. This cross-frequency coupling has been linked to working memory and spatial memory consolidation; however, its spatial and temporal dynamics remains unclear. Here, we first investigate the dynamics of theta-gamma interactions using multiple frequency and temporal scales in simultaneous recordings from hippocampal CA3, CA1, subiculum, and parietal cortex in freely moving mice. We found that theta phase dynamically modulates distinct gamma bands during REM sleep. Interestingly, we further show that theta-gamma coupling switches between recorded brain structures during REM sleep and progressively increases over a single REM sleep episode. Finally, we show that optogenetic silencing of septohippocampal GABAergic projections significantly impedes both theta-gamma coupling and theta phase coherence. Collectively, our study shows that phase-space (i.e. cross-frequency coupling) coding of information during REM sleep is orchestrated across time and space consistent with region-specific processing of information during REM sleep including learning and memory.
Création de la notice
06/07/2021 14:28
Dernière modification de la notice
07/07/2021 5:36
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