The number of Toll-like receptor 9-agonist motifs in the adenovirus genome correlates with induction of dendritic cell maturation by adenovirus immune complexes.

Détails

ID Serval
serval:BIB_B4299141A4E6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The number of Toll-like receptor 9-agonist motifs in the adenovirus genome correlates with induction of dendritic cell maturation by adenovirus immune complexes.
Périodique
Journal of Virology
Auteur(s)
Perreau M., Welles H.C., Pellaton C., Gjoksi B., Potin L., Martin R., Harari A., Bett A., Casimiro D., Gall J., Barouch D.H., Kremer E.J., Pantaleo G.
ISSN
1098-5514 (Electronic)
ISSN-L
0022-538X
Statut éditorial
Publié
Date de publication
2012
Volume
86
Numéro
11
Pages
6279-6285
Langue
anglais
Résumé
Adenovirus serotype 5 (Ad5) vectors and specific neutralizing antibodies (NAbs) generate immune complexes (ICs) which are potent inducers of dendritic cell (DC) maturation. Here we show that ICs generated with rare Ad vector serotypes, such as Ad26 and Ad35, which are lead candidates in HIV vaccine development, are poor inducers of DC maturation and that their potency in inducing DC maturation strongly correlated with the number of Toll-like receptor 9 (TLR9)-agonist motifs present in the Ad vector's genome. In addition, we showed that antihexon but not antifiber antibodies are responsible for the induction of Ad IC-mediated DC maturation.
Mots-clé
Adenoviruses, Human/genetics, Adenoviruses, Human/immunology, Amino Acid Motifs, Antibodies, Neutralizing/immunology, Antibodies, Viral/immunology, Antigen-Antibody Complex, Dendritic Cells/immunology, Dendritic Cells/virology, Humans, Toll-Like Receptor 9/agonists, Toll-Like Receptor 9/immunology, Viral Proteins/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/06/2012 17:22
Dernière modification de la notice
20/08/2019 15:22
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