Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study.

Détails

Ressource 1Télécharger: BIB_B423523DBF53.pdf (830.37 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_B423523DBF53
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study.
Périodique
BMC infectious diseases
Auteur(s)
Boillat-Blanco N., Bovet P., Ramaiya K.L., Mganga M., Minja L.T., Saleh L., Imboden M., Schindler C., Gagneux S., Daubenberger C., Reither K., Probst-Hensch N.
ISSN
1471-2334 (Electronic)
ISSN-L
1471-2334
Statut éditorial
Publié
Date de publication
03/11/2016
Peer-reviewed
Oui
Volume
16
Numéro
1
Pages
626
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish

Résumé
Vitamin D level is inversely associated with tuberculosis (TB) and diabetes (DM). Vitamin D could be a mediator in the association between TB and DM. We examined the associations between vitamin D, TB and DM.
Consecutive adults with TB and sex- and age-matched volunteers were included in a case-control study in Dar es Salaam, Tanzania. Glycemia and total vitamin D (25(OH)D) were measured at enrolment and after TB treatment in cases. The association between low 25(OH)D (<75 nmol/l) and TB was evaluated by logistic regression adjusted for age, sex, body mass index, socioeconomic status, sunshine hours, HIV and an interaction between low 25(OH)D and hyperglycemia.
The prevalence of low 25(OH)D was similar in TB patients and controls (25.8 % versus 31.0 %; p = 0.22). In the subgroup of patients with persistent hyperglycemia (i.e. likely true diabetic patients), the proportion of patients with low 25(OH)D tended to be greater in TB patients (50 % versus 29.7 %; p = 0.20). The effect modification by persistent hyperglycemia persisted in the multivariate analysis (pinteraction = 0.01).
Low 25(OH)D may increase TB risk in patients with underlying DM. Trials should examine if this association is causal and whether adjunct vitamin D therapy is beneficial in this population.

Pubmed
Open Access
Oui
Création de la notice
30/11/2016 21:51
Dernière modification de la notice
20/08/2019 15:22
Données d'usage