Traitement des infections severes: faut-il toujours administrer un aminoglycoside? [Treatment of severe infections: should one always administer an aminoglycoside?]

Détails

ID Serval
serval:BIB_B40AAFC6115B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Traitement des infections severes: faut-il toujours administrer un aminoglycoside? [Treatment of severe infections: should one always administer an aminoglycoside?]
Périodique
Schweizerische Medizinische Wochenschrift. Supplementum
Auteur(s)
Cometta  A., Baumgartner  J. D.
ISSN
0250-5525 (Print)
Statut éditorial
Publié
Date de publication
1996
Volume
76
Pages
28S-33S
Notes
English Abstract
Journal Article
Review
Résumé
Until recently, aminoglycoside antibiotics were the cornerstone for the treatment of severe infections. The rationale for using combination therapy containing beta-lactams and aminoglycosides was not only to broaden the antimicrobial spectrum but also to achieve enhanced bacterial killing by synergism and to prevent the emergence of antibiotic resistance. However, with the advent of new potent broad-spectrum and highly bactericidal antibiotics, the necessity of combining beta-lactams with aminoglycosides should be reassessed. This review questions the use of aminoglycosides in three severe infections frequently observed in intensive care units, nosocomial pneumonia, nosocomial sepsis and severe diffuse peritonitis. A review of the literature suggests that the addition of an aminoglycoside to a broad-spectrum beta-lactam does not improve the outcome in nosocomial pneumonia and severe diffuse peritonitis. However, the lack of large prospective studies in severe sepsis or septic shock makes it impossible to draw any conclusion about the addition of an aminoglycoside, and the administration of these agents must be decided on an individual basis.
Mots-clé
Aminoglycosides Anti-Bacterial Agents/administration & dosage/*therapeutic use Cross Infection/drug therapy Drug Resistance, Microbial Drug Therapy, Combination/therapeutic use Humans Lactams Peritonitis/*drug therapy Pneumonia, Bacterial/*drug therapy Sepsis/*drug therapy Shock, Septic/drug therapy
Pubmed
Création de la notice
25/01/2008 13:31
Dernière modification de la notice
20/08/2019 15:22
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