Neural differentiation and therapeutic potential of adipose tissue derived stem cells.

Détails

ID Serval
serval:BIB_B34B2A942E68
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Neural differentiation and therapeutic potential of adipose tissue derived stem cells.
Périodique
Current Stem Cell Research and Therapy
Auteur⸱e⸱s
Erba P., Terenghi G., Kingham P.J.
ISSN
1574-888X (Print)
Statut éditorial
Publié
Date de publication
2010
Volume
5
Numéro
2
Pages
153-160
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
Neural tissue has historically been regarded as having poor regenerative capacity but recent advances in the growing fields of tissue engineering and regenerative medicine have opened new hopes for the treatment of nerve injuries and neurodegenerative disorders. Adipose tissue has been shown to contain a large quantity of adult stem cells (ASC). These cells can be easily harvested with low associated morbidity and because of their potential to differentiate into multiple cell types, their use has been suggested for a wide variety of therapeutic applications. In this review we examine the evidence indicating that ASC can stimulate nerve regeneration by both undergoing neural differentiation and through the release of a range of growth factors. We also discuss some of the issues that need to be addressed before ASC can be developed as an effective cellular therapy for the treatment of neural tissue disorders.
Mots-clé
Adipose Tissue/pathology, Animals, Cell Lineage, Cell Survival, Cell Transdifferentiation, Humans, Induced Pluripotent Stem Cells/metabolism, Induced Pluripotent Stem Cells/pathology, Intercellular Signaling Peptides and Proteins/metabolism, Nerve Regeneration, Nerve Tissue/physiology, Neurodegenerative Diseases/pathology, Neurodegenerative Diseases/therapy, Neurogenesis, Stem Cell Niche/pathology, Stem Cell Transplantation
Pubmed
Web of science
Création de la notice
18/06/2011 13:52
Dernière modification de la notice
20/08/2019 15:21
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