Mechanisms of dexamethasone-induced insulin resistance in healthy humans
Détails
ID Serval
serval:BIB_B3443B6036D2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Mechanisms of dexamethasone-induced insulin resistance in healthy humans
Périodique
Journal of Clinical Endocrinology and Metabolism
ISSN
0021-972X (Print)
Statut éditorial
Publié
Date de publication
10/1994
Volume
79
Numéro
4
Pages
1063-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
Insulin resistance may result from decreased muscle blood flow, impaired cellular glucose transport, or intracellular deficits of glucose metabolism. The mechanisms responsible for dexamethasone-induced insulin resistance were investigated in healthy human subjects. During a 2-h hyperinsulinemic clamp, dexamethasone decreased glucose uptake, oxidation, and nonoxidative glucose disposal during the first hour. During the second hour, glucose uptake was normalized by means of hyperglycemia; glucose oxidation, however, remained suppressed by dexamethasone. Dexamethasone also abolished the insulin-mediated increase in calf blood flow. When acipimox was administered during the clamps to correct glucocorticoid-induced inhibition of glucose oxidation, dexamethasone decreased whole body glucose uptake and nonoxidative glucose disposal in the same proportion as when no acipimox was administered. However, glucose oxidation and insulin-mediated calf blood flow were normalized after acipimox. During the second hour, exogenous glucose infusion was matched to that used in the control clamp and normalized whole body glucose uptake. However, hyperglycemia developed, indicating insulin resistance. It is concluded that dexamethasone 1) decreases glucose oxidation independently of glucose transport; this inhibition is reversed by acipimox; and 2) decreases whole body glucose uptake independently of increased lipolysis, decreased glucose oxidation, or an altered muscle blood flow.
Mots-clé
Adult
Antilipemic Agents/pharmacology
Blood Glucose/analysis
Dexamethasone/*pharmacology
Female
Glucose/metabolism
Glucose Clamp Technique
Humans
Insulin/blood
*Insulin Resistance
Leg/blood supply
Male
Oxidation-Reduction/drug effects
Pyrazines/pharmacology
Regional Blood Flow/drug effects
Pubmed
Web of science
Création de la notice
24/01/2008 14:36
Dernière modification de la notice
20/08/2019 16:21