A high-fructose diet impairs basal and stress-mediated lipid metabolism in healthy male subjects.
Détails
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Etat: Public
Version: de l'auteur⸱e
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_B327FB1F0DEC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A high-fructose diet impairs basal and stress-mediated lipid metabolism in healthy male subjects.
Périodique
British Journal of Nutrition
ISSN
0007-1145
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
100
Numéro
2
Pages
393-399
Langue
anglais
Résumé
The effects of a 7 d high-fructose diet (HFrD) or control diet on lipid metabolism were studied in a group of six healthy lean males. Plasma NEFA and beta-hydroxybutyrate concentrations, net lipid oxidation (indirect calorimetry) and exogenous lipid oxidation (13CO2 production) were monitored in basal conditions, after lipid loading (olive oil labelled with [13C]triolein) and during a standardised mental stress. Lactate clearance and the metabolic effects of an exogenous lactate infusion were also monitored. The HFrD lowered plasma concentrations of NEFA and beta-hydroxybutyrate as well as lipid oxidation in both basal and after lipid-loading conditions. In addition, the HFrD blunted the increase in plasma NEFA and exogenous lipid oxidation during mental stress. The HFrD also increased basal lactate concentrations by 31.8 %, and lactate production by 53.8 %, while lactate clearance remained unchanged. Lactate infusion lowered plasma NEFA with the control diet, and net lipid oxidation with both the HFrD and control diet. These results indicate that a 7 d HFrD markedly inhibits lipolysis and lipid oxidation. The HFrD also increases lactate production, and the ensuing increased lactate utilisation may contribute to suppress lipid oxidation.
Mots-clé
3-Hydroxybutyric Acid, Adult, Basal Metabolism, Blood Glucose, Diet, Energy Metabolism, Fatty Acids, Nonesterified, Fructose, Humans, Lactic Acid, Lipid Metabolism, Male, Nutritional Physiological Phenomena, Stress, Psychological
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/10/2008 8:01
Dernière modification de la notice
20/08/2019 15:21