Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes.

Détails

Ressource 1Télécharger: 31478832_BIB_B2FCC082A445.pdf (865.87 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_B2FCC082A445
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes.
Périodique
eLife
Auteur(s)
Chaturvedi N., Svarovskaia E.S., Mo H., Osinusi A.O., Brainard D.M., Subramanian G.M., McHutchison J.G., Zeuzem S., Fellay J.
ISSN
2050-084X (Electronic)
ISSN-L
2050-084X
Statut éditorial
Publié
Date de publication
03/09/2019
Peer-reviewed
Oui
Volume
8
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Genetic polymorphism in the interferon lambda (IFN-λ) region is associated with spontaneous clearance of hepatitis C virus (HCV) infection and response to interferon-based treatment. Here, we evaluate associations between IFN-λ polymorphism and HCV variation in 8729 patients (Europeans 77%, Asians 13%, Africans 8%) infected with various viral genotypes, predominantly 1a (41%), 1b (22%) and 3a (21%). We searched for associations between rs12979860 genotype and variants in the NS3, NS4A, NS5A and NS5B HCV proteins. We report multiple associations in all tested proteins, including in the interferon-sensitivity determining region of NS5A. We also assessed the combined impact of human and HCV variation on pretreatment viral load and report amino acids associated with both IFN-λ polymorphism and HCV load across multiple viral genotypes. By demonstrating that IFN-λ variation leaves a large footprint on the viral proteome, we provide evidence of pervasive viral adaptation to innate immune pressure during chronic HCV infection.
Mots-clé
Adaptation, Biological, Africa, Asia, Europe, Genotype, Hepacivirus/genetics, Hepatitis C/immunology, Hepatitis C/virology, Humans, Immunologic Factors/genetics, Interferons/genetics, Viral Load, Viral Nonstructural Proteins/genetics, Hepatitis C, genetics, genome to genome analysis, genomics, human, infectious disease, integration analysis, interferon lambda polymorphism, microbiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/09/2019 17:33
Dernière modification de la notice
14/01/2021 10:38
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