Heterologous prime-boost regimen adenovector 35-circumsporozoite protein vaccine/recombinant Bacillus Calmette-Guérin expressing the Plasmodium falciparum circumsporozoite induces enhanced long-term memory immunity in BALB/c mice.

Détails

ID Serval
serval:BIB_B2AC3A3D8304
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Heterologous prime-boost regimen adenovector 35-circumsporozoite protein vaccine/recombinant Bacillus Calmette-Guérin expressing the Plasmodium falciparum circumsporozoite induces enhanced long-term memory immunity in BALB/c mice.
Périodique
Vaccine
Auteur(s)
Arama C., Assefaw-Redda Y., Rodriguez A., Fernández C., Corradin G., Kaufmann S.H., Reece S.T., Troye-Blomberg M.
ISSN
1873-2518 (Electronic)
ISSN-L
0264-410X
Statut éditorial
Publié
Date de publication
2012
Volume
30
Numéro
27
Pages
4040-4045
Langue
anglais
Résumé
BACKGROUND: Sustained antibody levels are a hallmark of immunity against many pathogens, and induction of long-term durable antibody titers is an essential feature of effective vaccines. Heterologous prime-boost approaches with vectors are optimal strategies to improve a broad and prolonged immunogenicity of malaria vaccines.
RESULTS: In this study, we demonstrate that the heterologous prime-boost regimen Ad35-CS/BCG-CS induces stronger immune responses by enhancing type 1 cellular producing-cells with high levels of CSp-specific IFN-γ and cytophilic IgG2a antibodies as compared to a homologous BCG-CS and a heterologous BCG-CS/CSp prime-boost regimen. Moreover, the heterologous prime-boost regimen elicits the highest level of LLPC-mediated immune responses.
CONCLUSION: The increased IFN-γ-producing cell responses induced by the combination of Ad35-CS/BCG-CS and sustained type 1 antibody profile together with high levels of LLPCs may be essential for the development of long-term protective immunity against liver-stage parasites.
Mots-clé
Adenoviruses, Human/genetics, Animals, Antibodies, Protozoan/blood, Drug Carriers/administration & dosage, Female, Genetic Vectors, Immunoglobulin G/blood, Immunologic Memory, Interferon-gamma/secretion, Malaria Vaccines/administration & dosage, Malaria Vaccines/genetics, Mice, Mice, Inbred BALB C, Mycobacterium bovis/genetics, Plasmodium falciparum/genetics, Plasmodium falciparum/immunology, Protozoan Proteins/genetics, Protozoan Proteins/immunology, Th1 Cells/immunology, Vaccination/methods, Vaccines, Synthetic/administration & dosage, Vaccines, Synthetic/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/07/2012 9:46
Dernière modification de la notice
20/08/2019 15:21
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