Rhodopsin topography and rod-mediated function in cats with the retinal degeneration of taurine deficiency
Détails
ID Serval
serval:BIB_B281A9385D17
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Rhodopsin topography and rod-mediated function in cats with the retinal degeneration of taurine deficiency
Périodique
Experimental Eye Research
ISSN
0014-4835 (Print)
Statut éditorial
Publié
Date de publication
10/1987
Volume
45
Numéro
4
Pages
481-90
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
Cats on a taurine-deficient diet were studied with imaging fundus reflectometry and full-field electroretinography. The pattern of rhodopsin loss and the natural history of the disease were determined from maps of the rhodopsin distribution in the central and nasal retina of cats with different degrees of severity of the retinopathy. Rhodopsin loss is first detectable in a focal region of the central retina. Subsequently, there are decreases in rhodopsin in the paracentral and nasal midperipheral retina. The horizontal streak of high rhodopsin levels is preferentially reduced in this retinopathy. The b-wave amplitude of the rod-dominated ERG is markedly reduced in cats with only mildly decreased levels of rhodopsin in the peripheral retina. In an affected cat with moderate rhodopsin loss in the central retina but minimal loss nasally, a light-microscopic study of the retina showed that there was disorganization and shortening of rod outer segments and loss of rod photoreceptor cells in the areas of reduced rhodopsin levels.
Mots-clé
Animals
Cats
Dark Adaptation
Electroretinography
Female
Fundus Oculi
Male
Photoreceptors/*physiopathology
Retina/metabolism
Retinal Degeneration/*metabolism/physiopathology
Retinal Pigments/*metabolism
Rhodopsin/*metabolism
Taurine/*metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 13:37
Dernière modification de la notice
20/08/2019 16:21