Comparison of thermogenic activity induced by the new sympathomimetic Ro 16-8714 between normal and obese subjects.

Détails

ID Serval
serval:BIB_B26AC47220C1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Comparison of thermogenic activity induced by the new sympathomimetic Ro 16-8714 between normal and obese subjects.
Périodique
International Journal of Obesity
Auteur(s)
Henny C., Bückert A., Schutz Y., Jéquier E., Felber J.P.
ISSN
0307-0565 (Print)
ISSN-L
0307-0565
Statut éditorial
Publié
Date de publication
1988
Volume
12
Numéro
3
Pages
227-236
Langue
anglais
Résumé
In a previous study, we demonstrated that the new beta-adrenoceptor agonist Ro 16-8714 possesses thermogenic property in normal male volunteers. The aim of the present study was to compare the metabolic response of lean vs obese individuals to a similar dose of this compound. Following an overnight fast, Ro 16-8714 (0.17 mg/kg fat free mass) or a placebo was given per os to six normal-weight subjects and to six moderately obese subjects. The rate of energy expenditure (EE) and the substrate utilization were determined by indirect calorimetry (hood system) before and for 6 h following the drug administration. Heart rate and blood pressure as well as plasma glucose, insulin and free fatty acid (FFA) concentrations were also measured at regular intervals throughout the study. The increment relative to base-line (mean +/- s.e.m.) in EE was similar in the two groups and averaged 4.0 +/- 1.4 per cent and 12.2 +/- 1.4 per cent with placebo and with Ro 16-8714 respectively in lean subjects, whereas the values reached 3.5 +/- 1.2 per cent and 14.4 +/- 2.0 per cent in obese subjects. Heart rate, systolic blood pressure, insulin and FFA were increased without any significant difference between the two groups. This study shows that Ro 16-8714 is a potent thermogenic agent both in normal and obese subjects.
Mots-clé
2-Hydroxyphenethylamine/analogs & derivatives, 2-Hydroxyphenethylamine/pharmacology, Adrenergic beta-Agonists/pharmacology, Adult, Basal Metabolism/drug effects, Blood Pressure/drug effects, Body Temperature Regulation/drug effects, Carbohydrate Metabolism, Energy Metabolism/drug effects, Female, Heart Rate/drug effects, Humans, Lipid Metabolism, Male, Obesity/metabolism, Oxidation-Reduction, Phenethylamines/pharmacology
Pubmed
Web of science
Création de la notice
21/01/2008 13:07
Dernière modification de la notice
20/08/2019 15:21
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