Evidence of positive selection on the Atlantic salmon CD3gammadelta gene.
Détails
ID Serval
serval:BIB_B25D7C9F2FB3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Evidence of positive selection on the Atlantic salmon CD3gammadelta gene.
Périodique
Immunogenetics
ISSN
0093-7711
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
59
Numéro
3
Pages
225-232
Langue
anglais
Résumé
Atlantic salmon are typically anadromous, spending the majority of their lifetime in oceans and returning to fresh water to breed. This diversity of environments likely results in strong selective forces shaping their genome. In this paper, we present the first genomics approach to detect positive selection operating on the Salmo salar (salmon) lineage, an important aquaculture species. We identify a panel of candidate genes that may have been subject to adaptive evolution in this species. In particular, we identify a robust signature of positive selection operating on the salmon CD3gammadelta gene, which encodes one of the protein chains essential for formation of the T-cell receptor complex and for T-cell activation. Furthermore, we identified the particular codon sites that have been subject to positive selection in fish and highlight two sites flanking an important N-glycosylation site in this molecule.
Mots-clé
Amino Acid Sequence, Animals, Antigens, CD3/genetics, Codon, Evolution, Molecular, Molecular Sequence Data, Oncorhynchus mykiss, Phylogeny, Salmo salar/genetics, Selection (Genetics), Sequence Homology, Amino Acid
Pubmed
Web of science
Création de la notice
11/03/2008 7:34
Dernière modification de la notice
20/08/2019 15:21