Multiple courses of antenatal corticosteroids for preterm birth study: 2-year outcomes.
Détails
ID Serval
serval:BIB_B25674FAC192
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Multiple courses of antenatal corticosteroids for preterm birth study: 2-year outcomes.
Périodique
Pediatrics
Collaborateur⸱rice⸱s
Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study Collaborative Group
ISSN
1098-4275[electronic], 0031-4005[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
126
Numéro
5
Pages
e1045-e1055
Langue
anglais
Notes
; Schmaltz (Luiza Emylce Pela Rosado) LE ; Bueno (Goianice Ribeiro de Souza Georgia) GR ; de Sa (Renato Augusto Moreira) RA ; Bornia (Rita Guerios) RG ; Morsch (Denise Sterit) DS ; Porto (Maria Amelia Sayeg Campos) MA ; Demianczuk (Nestor N) NN ; Pentinnen (Elizabeth) E ; Mackoway (Jacqui) J ; Hendson (Leonora) L ; Tomlinson (Jill) J ; Butt (Kimberly) K ; Hay (Kathryn) K ; Krishnaswamy (R) R ; Ward (Karen) K ; Armson (B Anthony) BA ; Vincer (Michael) M ; Allen (Victoria) V ; Fanning (Cora) C ; Kulkarni (Ramesh) R ; Laplante (Joanne) J ; Scarfoni (Rhonda) R ; Carson (George D) GD ; Williams (Suzanne) S ; Holfeld (Sandy) S ; Fontaine (Leanne) L ; Bigalky (Jodie) J ; Olatunbosun (Olufemi) O ; Henry (April) A ; Erker (Linda) L ; Wonko (Neil) N ; Haughian (Janna) J ; Dalton (Shirley) S ; Moutquin (Jean-Marie) JM ; Blouin (Daniel) D ; Bédard (Suzanne Kocsis) SK ; Ferretti (Emanuela) E ; Murphy (Kellie) K ; Ohlsson (Arne) A ; Kelly (Edmond) E ; Jordan (Anne) A ; Shapiro (Jodi) J ; Sananes (Renee) R ; Cooper (Laura) L ; Fernandes-Penny (Alda) A ; Asztalos (Elizabeth) E ; Hohn (Denise) D ; Lacy (Maralyn) M ; Delisle (Marie-France) MF ; Synnes (Anne) A ; Popovska (Vesna) V ; Soanes (Shelly) S ; Sauter (Agnes) A ; Helewa (Michael E) ME ; Kenny-Lodewyks (Doris) D ; Moddemann (Diane) D ; Granke (Naomi) N ; Penner (Karen) K ; Gomez (Ricardo) R ; Neculman (Karla Silva) KS ; Castro (Juan Andres Ortiz) JA ; Solari (Manuel Schepeler) MS ; Rojas (Mario Alfredo Carstens) MA ; Poblete (Jorge Figueroa) JF ; Gonzalez (Patricia Urrutia) PU ; Schifferli (Monica Troncoso) MT ; Aguilera (Lilian Saez) LS ; Belmar (Cristian) C ; Moore (Rosario) R ; Vera (Claudio) C ; Kattan (Javier) J ; Su (Qi Feng) QF ; Gu (Wei) W ; Liu (Zhi Wei) ZW ; Flores (Martha Marrugo) MM ; Santoro (Carlos Malabet) CM ; López (Jaime Galindo) JG ; Ortiz (Edgar Ivan) EI ; Torres (Javier) J ; Sanchez (Adriana Rodriguez) AR ; Hvidman (Lone) L ; Mouritzen (Anne) A ; Vikre-Jørgensen (Jennifer) J ; Christiansen (Marianne B) MB ; Hopp (Hartmut) H ; Nonnenmacher (Andreas) A ; Hoyme (Udo B) UB ; Bittrich (Hans-Jorg) HJ ; Oletzky (Britta) B ; Hollwitz (Bettina) B ; Oehler (Katrin) K ; Dressler (Frank) F ; Meng-Hentschel (Juliane) J ; Faber (Renaldo) R ; Stepan (Holger) H ; Pulzer (Ferdinand) F ; Kuhnert (Maritta) M ; Stiller (Susanne) S ; Kuschel (Bettina) B ; Schneider (K T M) KT ; Zimmermann (Andrea) A ; Krause (Michael) M ; Korausova (Jana) J ; Seelbach-Goebel (Birgit) B ; Falkert (Andreas) A ; Mueller (Karin) K ; Voss (Hana) H ; Major (Tamas) T ; Krasznai (Zoárd) Z ; Bartha (Tünde) T ; Polonkai (Edit) E ; Zsadányi (Judit) J ; Nachum (Zohar) Z ; Felszer (Clari) C ; Hallak (Mordechai) M ; Harlev (Avraham) A ; Walfisch (Asnat) A ; Gortzak-Uzan (Limor) L ; Galil (Aharon) A ; Harel (Linda) L ; Chayen (Benny) B ; Siev (Sima) S ; Samberg (Ichel) I ; Wolff (Leslie) L ; Sadan (Oscar) O ; Kohelet (David) D ; Golan (Abraham) A ; Kerem (Ein) E ; Mankuta (David) D ; Bar-oz (Benny) B ; Rosen (Doron J D) DJ ; Kaneti (Hagai) H ; Zausmer (Janice) J ; Regev (Rivka) R ; Klinger (Gil) G ; Tirosh (Naama) N ; Naor (Norah) N ; Simchen (Michal) M ; Shalev (Gilat) G ; Goldinfeld (Michael) M ; Levine (Orit) O ; El-Zibdeh (Mazen Y) MY ; Al-Faris (Lama) L ; Ugarte (Pedro Saona) PS ; Montalvo (Sicillia Bellomo) SB ; Preis (Krzysztof) K ; Swiatkowska-Freund (Malgorzata) M ; Janczewska (Iwona) I ; Wilczynski (Jan) J ; Krekora (Michael) M ; Kesiak (Marcin) M ; Gulczyńska (Eva) E ; Breborowicz (Grzegorz H) GH ; Madejczyk (Mateusz) M ; Rozycka (Joanna) J ; Montgomery (Agnieszka) A ; Szymankiewicz (Marta) M ; Borzova (Nadezhda) N ; Posiseeva (Lubov V) LV ; Khodzhaeva (Zulfiya S) ZS ; Vikhlyaeva (Ekaterina M) EM ; Grebennikova (Natalya V) NV ; Baibarina (Elena N) EN ; Palacio (Montse) M ; Botet (Francesc) F ; Cobo (Teresa) T ; Pisa (Sonia) S ; Salvia (Dolors) D ; Hösli (Irene) I ; Holzgreve (Wolfgang) W ; Voekt (Cora A) CA ; Forcada-Guex (Margarita) M ; Moessinger (Adrian) A ; Bickle-Graz (Myriam) M ; Beinder (Ernst) E ; von Mandach (Ursula) U ; Fauchere (Jean-Claude) JC ; Roumen (Frans J M E) FJ ; Wynands (J B G) JB ; Gavilanes (Antonio W D) AW ; Bolaji (Ibrahim I) II ; Adiotomre (Pauline) P ; Al-Taher (Hamed) H ; Barnes (Hayley) H ; Rubin (Susan) S ; Abdul-Kadir (Rezan) R ; Chi (Claudia) C ; Van Someren (Vivienne) V ; Pardanani (Setul) S ; Bebbington (Michael) M ; Chazotte (Cynthia) C ; Kilpatrick (Sarah) S ; Drahos (Jessica L) JL ; Bsat (Fadi) F ; Fleming (Jennie) J ; Lee (Alison) A ; Hoffman (Despina) D ; Bracken (M) M ; Crowley (P) P ; Duley (L) L ; Erenkranz (R) R ; Thorpe (K) K ;
Résumé
The aim of this study was to determine the effects of repeated courses of prenatal corticosteroid therapy versus placebo on death or neurologic impairment among the children enrolled in the Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study, at 18 to 24 months of age.
A total of 2305 infants were eligible for follow-up evaluation; 2104 infants (1069 in the prenatal corticosteroid therapy group and 1035 in the placebo group) were monitored. The primary outcome was death or neurologic impairment, defined as either cerebral palsy or cognitive delay, at 18 to 24 months of age. The secondary outcomes were measurements of growth (height, weight, and head circumference).
Children exposed to multiple courses of prenatal corticosteroid therapy had similar rates of death or neurologic impairment, compared with children exposed to placebo (148 children [13.8%] vs 142 children [13.7%]; odds ratio: 1.001[95% confidence interval: 0.75-1.30]; P = .95). They had a mean weight of 11.94 kg, compared with 12.14 kg in the placebo group (P = .04), a mean height of 85.51 cm, compared with 85.46 cm (P = .87), and a mean head circumference of 48.18 cm, compared with 48.25 cm (P = .45).
Multiple courses of prenatal corticosteroid therapy, given every 14 days, did not increase or decrease the risk of death or neurologic impairment at 18 to 24 months of age, compared with a single course of prenatal corticosteroid therapy. Continued follow-up monitoring of these children is necessary to assess neurobehavioral function, school performance, and possible susceptibility to disease.
A total of 2305 infants were eligible for follow-up evaluation; 2104 infants (1069 in the prenatal corticosteroid therapy group and 1035 in the placebo group) were monitored. The primary outcome was death or neurologic impairment, defined as either cerebral palsy or cognitive delay, at 18 to 24 months of age. The secondary outcomes were measurements of growth (height, weight, and head circumference).
Children exposed to multiple courses of prenatal corticosteroid therapy had similar rates of death or neurologic impairment, compared with children exposed to placebo (148 children [13.8%] vs 142 children [13.7%]; odds ratio: 1.001[95% confidence interval: 0.75-1.30]; P = .95). They had a mean weight of 11.94 kg, compared with 12.14 kg in the placebo group (P = .04), a mean height of 85.51 cm, compared with 85.46 cm (P = .87), and a mean head circumference of 48.18 cm, compared with 48.25 cm (P = .45).
Multiple courses of prenatal corticosteroid therapy, given every 14 days, did not increase or decrease the risk of death or neurologic impairment at 18 to 24 months of age, compared with a single course of prenatal corticosteroid therapy. Continued follow-up monitoring of these children is necessary to assess neurobehavioral function, school performance, and possible susceptibility to disease.
Mots-clé
Adrenal Cortex Hormones/administration & dosage, Adrenal Cortex Hormones/adverse effects, Birth Weight/drug effects, Body Height/drug effects, Cephalometry, Cerebral Palsy/chemically induced, Cerebral Palsy/mortality, Child, Preschool, Drug Administration Schedule, Female, Follow-Up Studies, Gestational Age, Humans, Infant, Infant, Newborn, Male, Mental Retardation/chemically induced, Mental Retardation/mortality, Pregnancy, Premature Birth/prevention & control, Prenatal Care, Respiratory Distress Syndrome, Newborn/prevention & control
Pubmed
Création de la notice
15/02/2011 12:40
Dernière modification de la notice
20/08/2019 16:21
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