A 50-year-old woman rapidly developed ascites with jaundice and worsening of general condition. On admission a nodule of the left breast was noted. Workup showed slight anomalies in liver tests and led to the diagnosis of portal hypertension, without visible lesion (CT scan, ultrasonography) of the liver. The patient suffered severe bleeding caused by esophageal varices necessitating urgent sclerotherapy. Several days later, her condition worsened rapidly due to acute respiratory distress syndrome followed by irreversible shock.