Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index.

Détails

Ressource 1Télécharger: BIB_B24DBE741EAD.P001.pdf (520.35 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_B24DBE741EAD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index.
Périodique
PLoS Genetics
Auteur⸱e⸱s
Hoggart C.J., Venturini G., Mangino M., Gomez F., Ascari G., Zhao J.H., Teumer A., Winkler T.W., Ternikova N., Luan J., Mihailov E., Ehret G.B., Zhang W., Lamparter D., Esko T., Macé A., Rüeger S., Bochud P.Y., Barcella M., Dauvilliers Y., Benyamin B., Evans D.M., Hayward C., Lopez M.F., Franke L., Russo A., Heid I.M., Salvi E., Vendantam S., Arking D.E., Boerwinkle E., Chambers J.C., Fiorito G., Grallert H., Guarrera S., Homuth G., Huffman J.E., Porteous D., Moradpour D., Moradpour D., Iranzo A., Hebebrand J., Kemp J.P., Lammers G.J., Aubert V., Heim M.H., Martin N.G., Montgomery G.W., Peraita-Adrados R., Santamaria J., Negro F., Schmidt C.O., Scott R.A., Spector T.D., Strauch K., Völzke H., Wareham N.J., Yuan W., Bell J.T., Chakravarti A., Kooner J.S., Peters A., Matullo G., Wallaschofski H., Whitfield J.B., Paccaud F., Vollenweider P., Bergmann S., Beckmann J.S., Tafti M., Hastie N.D., Cusi D., Bochud M., Frayling T.M., Metspalu A., Jarvelin M.R., Scherag A., Smith G.D., Borecki I.B., Rousson V., Hirschhorn J.N., Rivolta C., Loos R.J., Kutalik Z.
Collaborateur⸱rice⸱s
Generation Scotland Consortium, LifeLines Cohort study, GIANT Consortium
ISSN
1553-7404 (Electronic)
ISSN-L
1553-7390
Statut éditorial
Publié
Date de publication
2014
Volume
10
Numéro
7
Pages
e1004508
Langue
anglais
Résumé
The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six lead SNPs were carried forward for replication in five family-based studies (of ∼4,000 trios). Two SNPs replicated: the paternal rs2471083-C allele (located near the imprinted KCNK9 gene) and the paternal rs3091869-T allele (located near the SLC2A10 gene) increased BMI equally (beta = 0.11 (SD), P<0.0027) compared to the respective maternal alleles. Real-time PCR experiments of lymphoblastoid cell lines from the CEPH families showed that expression of both genes was dependent on parental origin of the SNPs alleles (P<0.01). Our scheme opens new opportunities to exploit GWAS data of unrelated individuals to identify POEs and demonstrates that they play an important role in adult obesity.
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/09/2014 17:18
Dernière modification de la notice
20/08/2019 15:21
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