Morphometric features of drug-resistant essential tremor and recovery after stereotactic radiosurgical thalamotomy.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_B24A0191BFE7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Morphometric features of drug-resistant essential tremor and recovery after stereotactic radiosurgical thalamotomy.
Périodique
Network neuroscience
Auteur⸱e⸱s
Bolton TAW, Van De Ville D., Régis J., Witjas T., Girard N., Levivier M., Tuleasca C.
ISSN
2472-1751 (Electronic)
ISSN-L
2472-1751
Statut éditorial
Publié
Date de publication
07/2022
Peer-reviewed
Oui
Volume
6
Numéro
3
Pages
850-869
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Essential tremor (ET) is the most common movement disorder. Its neural underpinnings remain unclear. Here, we quantified structural covariance between cortical thickness (CT), surface area (SA), and mean curvature (MC) estimates in patients with ET before and 1 year after ventro-intermediate nucleus stereotactic radiosurgical thalamotomy, and contrasted the observed patterns with those from matched healthy controls. For SA, complex rearrangements within a network of motion-related brain areas characterized patients with ET. This was complemented by MC alterations revolving around the left middle temporal cortex and the disappearance of positive-valued covariance across both modalities in the right fusiform gyrus. Recovery following thalamotomy involved MC readjustments in frontal brain centers, the amygdala, and the insula, capturing nonmotor characteristics of the disease. The appearance of negative-valued CT covariance between the left parahippocampal gyrus and hippocampus was another recovery mechanism involving high-level visual areas. This was complemented by the appearance of negative-valued CT/MC covariance, and positive-valued SA/MC covariance, in the right inferior temporal cortex and bilateral fusiform gyrus. Our results demonstrate that different morphometric properties provide complementary information to understand ET, and that their statistical cross-dependences are also valuable. They pinpoint several anatomical features of the disease and highlight routes of recovery following thalamotomy.
Mots-clé
Cortical thickness, Essential tremor, Mean curvature, Morphometry, Radiosurgery, Structural covariance analysis, Surface area, Thalamotomy, Ventro-intermediate nucleus
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/10/2022 13:55
Dernière modification de la notice
23/01/2024 7:32
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