Sex differences in the cerebral function associated with processing of aversive stimuli by schizophrenia patients

Détails

ID Serval
serval:BIB_B216B0021219
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Sex differences in the cerebral function associated with processing of aversive stimuli by schizophrenia patients
Périodique
The Australian and New Zealand journal of psychiatry
Auteur(s)
Mendrek A., Mancini-Marië A., Fahim C., Stip E.
ISSN
0004-8674
Statut éditorial
Publié
Date de publication
2007
Volume
41
Numéro
2
Pages
136-41
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
OBJECTIVE: Impaired processing of various emotions is considered one of the fundamental features of schizophrenia. In the recent study intriguing sex differences were observed in the cerebral function associated with the experience of sadness in schizophrenia patients. The aim of the present study was to explore this phenomenon during exposure to aversive stimuli. METHOD: Fifteen men and 10 women with the DSM-IV diagnosis of schizophrenia underwent functional magnetic resonance imaging (fMRI) while viewing alternating blocks of negative and neutral pictures. Data were analysed using random-effects model within statistical parametric mapping (SPM99) software. RESULTS: Processing of negative stimuli evoked significantly greater activations in men in the thalamus, cerebellum, temporal, occipital and posterior cingulate cortex, while women exhibited greater activations in the left middle frontal gyrus. CONCLUSIONS: The sex differences in the cerebral activations in schizophrenia patients deviate from what has been observed in the general population during exposure and experience of negative affect. As such the present study supports and extends the authors' preliminary observation of the anomalous sexual dimorphism in schizophrenia at the functional neuroanatomical level, suggesting potential masculinization of female subjects and feminization of male subjects with schizophrenia.
Mots-clé
Adult, Affect, Antipsychotic Agents / therapeutic use, Cerebral Cortex / anatomy & histology, Cerebral Cortex / physiopathology, Cognition Disorders / diagnosis, Cognition Disorders / epidemiology, Data Interpretation, Statistical, Diagnostic and Statistical Manual of Mental Disorders, Drug Administration Schedule, Escape Reaction, Female, Humans, Magnetic Resonance Imaging, Male, Perceptual Disorders / diagnosis, Perceptual Disorders / epidemiology, Schizophrenia / drug therapy, Schizophrenia / epidemiology, Sex Distribution
Pubmed
Création de la notice
24/06/2009 13:37
Dernière modification de la notice
20/08/2019 15:20
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