Interet du dosage des steroides plasmatiques dans le controle de l'hyperplasie surrenale congenitale. [Value of the assay of plasma steroids in the control of congenital adrenal hyperplasia]
Détails
ID Serval
serval:BIB_B1EB9242470D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Interet du dosage des steroides plasmatiques dans le controle de l'hyperplasie surrenale congenitale. [Value of the assay of plasma steroids in the control of congenital adrenal hyperplasia]
Périodique
Archives Françaises de Pediatrie
ISSN
0929-693X
0003-9764 (Print)
0003-9764 (Print)
Statut éditorial
Publié
Date de publication
03/1985
Volume
42
Numéro
3
Pages
211-7
Notes
English Abstract
Journal Article --- Old month value: Mar
Journal Article --- Old month value: Mar
Résumé
Twenty patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency have been followed during a mean period of 68.4 months (from 19 to 120 months). Plasma 17 alpha-hydroxyprogesterone, delta 4-androstenedione and testosterone have been measured at regular intervals and correlated to growth and bone maturation. Satisfactory growth was obtained through repeated changes in the daily dose of oral hydrocortisone which varied from 58.7 +/- 37 mg/m2/day in infants to respectively 19.3 +/- 7.0 and 25.3 +/- 7.2 mg/m2/day in prepuberty and puberty. Fludrocortisone was added in 15 cases because of evidence of salt loss. delta 4-androstenedione and 17 alpha-hydroxyprogesterone are the best markers of adequate suppression of the pituitary-adrenal axis in both sexes. Testosterone can be used in girls and prepubertal boys. In some cases with low levels of androgens suggesting oversuppression, a reduced velocity of bone maturation was observed, particularly in young subjects.
Mots-clé
17-alpha-Hydroxyprogesterone
Adolescent
Adrenal Hyperplasia, Congenital/*blood/drug therapy
Androstenedione/*blood
Body Height
Child, Preschool
Female
Follow-Up Studies
Humans
Hydrocortisone/administration & dosage/therapeutic use
Hydroxyprogesterones/*blood
Infant
Male
Testosterone/*blood
Time Factors
Pubmed
Web of science
Création de la notice
25/01/2008 11:31
Dernière modification de la notice
20/08/2019 16:20