Stabilised beta-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death.

Détails

ID Serval
serval:BIB_B1DC71F5CCDC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Stabilised beta-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death.
Périodique
Basic Research in Cardiology
Auteur⸱e⸱s
Hirschy Alain, Croquelois Adrien, Perriard Evelyne, Schoenauer Roman, Agarkova Irina, Hoerstrup Simon P., Taketo Makoto M., Pedrazzini Thierry, Perriard Jean-Claude, Ehler Elisabeth
ISSN
1435-1803[electronic], 0300-8428[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
105
Numéro
5
Pages
597-608
Langue
anglais
Résumé
Beta-catenin is a component of the intercalated disc in cardiomyocytes, but can also be involved in signalling and activation of gene transcription. We wanted to determine how long-term changes in beta-catenin expression levels would affect mature cardiomyocytes. Conditional transgenic mice that either lacked beta-catenin or that expressed a non-degradable form of beta-catenin in the adult ventricle were created. While mice lacking beta-catenin in the ventricle do not have an overt phenotype, mice expressing a non-degradable form develop dilated cardiomyopathy and do not survive beyond 5 months. A detailed analysis could reveal that this phenotype is correlated with a distinct localisation of beta-catenin in adult cardiomyocytes, which cannot be detected in the nucleus, no matter how much protein is present. Our report is the first study that addresses long-term effects of either the absence of beta-catenin or its stabilisation on ventricular cardiomyocytes and it suggests that beta-catenin's role in the nucleus may be of little significance in the healthy adult heart.
Mots-clé
myocyte-specific excision, cardiac-hypertrophy, intercalated disc, signaling pathway, mouse development, nuclear-membrane, progenitor cells, protein emerin, cancer cells, gene, Beta-catenin, Hypertrophy, Intercalated disc, Canonical Wnt signalling, Dilated cardiomyopathy
Pubmed
Web of science
Création de la notice
25/08/2010 11:36
Dernière modification de la notice
20/08/2019 16:20
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