Exaggerated endothelin release in high-altitude pulmonary edema

Détails

ID Serval
serval:BIB_B1BDD2D5B682
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Exaggerated endothelin release in high-altitude pulmonary edema
Périodique
Circulation
Auteur⸱e⸱s
Sartori  C., Vollenweider  L., Loffler  B. M., Delabays  A., Nicod  P., Bartsch  P., Scherrer  U.
ISSN
1524-4539 (Electronic)
Statut éditorial
Publié
Date de publication
05/1999
Volume
99
Numéro
20
Pages
2665-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May 25
Résumé
BACKGROUND: Exaggerated pulmonary hypertension is thought to play an important part in the pathogenesis of high-altitude pulmonary edema (HAPE). Endothelin-1 is a potent pulmonary vasoconstrictor peptide that also augments microvascular permeability. METHODS AND RESULTS: We measured endothelin-1 plasma levels and pulmonary artery pressure in 16 mountaineers prone to HAPE and in 16 mountaineers resistant to this condition at low (580 m) and high (4559 m) altitudes. At high altitude, in mountaineers prone to HAPE, mean (+/-SE) endothelin-1 plasma levels were approximately 33% higher than in HAPE-resistant mountaineers (22.2+/-1.1 versus 16.8+/-1.1 pg/mL, P<0.01). There was a direct relationship between the changes from low to high altitude in endothelin-1 plasma levels and systolic pulmonary artery pressure (r=0.82, P<0.01) and between endothelin-1 plasma levels and pulmonary artery pressure measured at high altitude (r=0.35, P=0.05). CONCLUSIONS: These findings suggest that in HAPE-susceptible mountaineers, an augmented release of the potent pulmonary vasoconstrictor peptide endothelin-1 and/or its reduced pulmonary clearance could represent one of the mechanisms contributing to exaggerated pulmonary hypertension at high altitude.
Mots-clé
Adult *Altitude Blood Pressure/physiology Disease Susceptibility Endothelin-1/blood/*metabolism Female Humans Male Middle Aged Mountaineering/physiology Pulmonary Artery/physiopathology Pulmonary Edema/*etiology/*metabolism/physiopathology Systole
Pubmed
Web of science
Création de la notice
25/01/2008 14:00
Dernière modification de la notice
20/08/2019 15:20
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