Lack of in vitro biofilm formation does not attenuate the virulence of Streptococcus gordonii in experimental endocarditis.

Détails

ID Serval
serval:BIB_B17260B8FD45
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Lack of in vitro biofilm formation does not attenuate the virulence of Streptococcus gordonii in experimental endocarditis.
Périodique
FEMS Immunology and Medical Microbiology
Auteur(s)
Bizzini A., Beggah-Möller S., Moreillon P., Entenza J.M.
ISSN
0928-8244[print], 0928-8244[linking]
Statut éditorial
Publié
Date de publication
2006
Volume
48
Numéro
3
Pages
419-423
Langue
anglais
Résumé
The ability to induce experimental endocarditis of biofilm-deficient mutants of Streptococcus gordonii was studied in an isogenic background. Strains were inactivated in either comD, fruK or pbp2b genes, which are involved in biofilm formation. These strains were clearly impaired (>75% reduction) in biofilm production in vitro. However, this did not result in a decreased severity of infection in vivo.
Mots-clé
Animals, Bacterial Adhesion/genetics, Bacterial Adhesion/physiology, Biofilms/growth & development, Disease Models, Animal, Endocarditis, Bacterial/microbiology, Female, Rats, Streptococcal Infections/microbiology, Streptococcus/genetics, Streptococcus/pathogenicity, Virulence/genetics, Virulence/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 13:45
Dernière modification de la notice
20/08/2019 15:20
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