Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer.

Détails

Ressource 1Télécharger: BIB_B164E811B26B.P001.pdf (1853.17 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_B164E811B26B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer.
Périodique
Trends in Cell Biology
Auteur(s)
Goruppi S., Dotto G.P.
ISSN
1879-3088 (Electronic)
ISSN-L
0962-8924
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
23
Numéro
12
Pages
593-602
Langue
anglais
Résumé
Multifocal and recurrent epithelial tumors, originating from either dormant or de novo cancer cells, are major causes of morbidity and mortality. The age-dependent increase of cancer incidence has long been assumed to result from the sequential accumulation of cancer-driving or -facilitating mutations with induction of cellular senescence as a protective mechanism. However, recent evidence suggests that the initiation and development of epithelial cancer results from a close interplay with its altered tissue microenvironment, with chronic inflammation, stromal senescence, autophagy, and the activation of cancer-associated fibroblasts (CAFs) playing possible primary roles. We will discuss recent progress in these areas, and highlight how this understanding may be used for devising novel preventive and therapeutic approaches to the epithelial cancer problem.
Mots-clé
Animals, Bufonidae/anatomy & histology, Dimethoate/toxicity, Epidermis/drug effects, Larva, Melanophores/drug effects, Time Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/01/2014 9:04
Dernière modification de la notice
20/08/2019 15:20
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