Aggressive pituitary neuroendocrine tumors: current practices, controversies, and perspectives, on behalf of the EANS skull base section.

Détails

ID Serval
serval:BIB_B14CC22B3644
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Aggressive pituitary neuroendocrine tumors: current practices, controversies, and perspectives, on behalf of the EANS skull base section.
Périodique
Acta neurochirurgica
Auteur⸱e⸱s
Ng S., Messerer M., Engelhardt J., Bruneau M., Cornelius J.F., Cavallo L.M., Cossu G., Froelich S., Meling T.R., Paraskevopoulos D., Schroeder HWS, Tatagiba M., Zazpe I., Berhouma M., Daniel R.T., Laws E.R., Knosp E., Buchfelder M., Dufour H., Gaillard S., Jacquesson T., Jouanneau E.
ISSN
0942-0940 (Electronic)
ISSN-L
0001-6268
Statut éditorial
Publié
Date de publication
11/2021
Peer-reviewed
Oui
Volume
163
Numéro
11
Pages
3131-3142
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Aggressive pituitary neuroendocrine tumors (APT) account for 10% of pituitary tumors. Their management is a rapidly evolving field of clinical research and has led pituitary teams to shift toward a neuro-oncological-like approach. The new terminology "Pituitary neuroendocrine tumors" (PitNet) that was recently proposed to replace "pituitary adenomas" reflects this change of paradigm. In this narrative review, we aim to provide a state of the art of actual knowledge, controversies, and recommendations in the management of APT. We propose an overview of current prognostic markers, including the recent five-tiered clinicopathological classification. We further establish and discuss the following recommendations from a neurosurgical perspective: (i) surgery and multi-staged surgeries (without or with parasellar resection in symptomatic patients) should be discussed at each stage of the disease, because it may potentialize adjuvant medical therapies; (ii) temozolomide is effective in most patients, although 30% of patients are non-responders and the optimal timeline to initiate and interrupt this treatment remains questionable; (iii) some patients with selected clinicopathological profiles may benefit from an earlier local radiotherapy and/or chemotherapy; (iv) novel therapies such as VEGF-targeted therapies and anti-CTLA-4/anti-PD1 immunotherapies are promising and should be discussed as 2nd or 3rd line of treatment. Finally, whether neurosurgeons have to operate on "pituitary adenomas" or "PitNets," their role and expertise remain crucial at each stage of the disease, prompting our community to deal with evolving concepts and therapeutic resources.
Mots-clé
Adenoma, Humans, Neuroendocrine Tumors, Pituitary Gland, Pituitary Neoplasms/surgery, Skull Base, Aggressive pituitary adenoma, Atypical pituitary adenoma, Endocrine tumors, Neuro-oncology, PitNet, Pituitary carcinoma, Radiotherapy, Temozolomide, Transsphenoidal surgery
Pubmed
Web of science
Création de la notice
20/08/2021 15:23
Dernière modification de la notice
18/10/2023 6:11
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