Generalized Anxiety Disorder is Prospectively Associated With Decreased Levels of Interleukin-6 and Adiponectin Among Individuals from the Community.

Détails

ID Serval
serval:BIB_B13604E0C1A0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Generalized Anxiety Disorder is Prospectively Associated With Decreased Levels of Interleukin-6 and Adiponectin Among Individuals from the Community.
Périodique
Journal of affective disorders
Auteur(s)
Wagner E.N., Strippoli M.F., Ajdacic-Gross V., Gholam-Rezaee M., Glaus J., Vandeleur C., Vollenweider P., Preisig M., von Känel R.
ISSN
1573-2517 (Electronic)
ISSN-L
0165-0327
Statut éditorial
Publié
Date de publication
01/06/2020
Peer-reviewed
Oui
Volume
270
Pages
114-117
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Anxiety disorders have been related to cardiovascular diseases via low-grade inflammation, but longitudinal studies on the association between generalized anxiety disorder (GAD) and inflammatory biomarkers are sparse. Furthermore, no studies have examined the association between GAD and the "cardio-protective" adipocytokine adiponectin in this context so far.
In a Swiss population-based sample of 2,415 adults participating in baseline and follow-up exams (mean follow-up duration=5.5 years), we diagnosed a total of 55 persons (2.3%) with GAD using a validated semi-structured psychiatric interview. We prospectively examined the relation between GAD and circulating levels of inflammatory biomarkers (i.e., C-reactive protein, interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and adiponectin), in linear regression models, statistically controlled for the baseline inflammatory marker, socioeconomic status, cardiovascular risk factors, health behaviors, and psychiatric disorders.
Compared to those without GAD, individuals with GAD had lower IL-6 (β=-0.249, 95%-CI -0.493-(-0.004), p=0.046), and adiponectin (β=-0.264, 95%-CI -0.482-(-0.045), p=0.018) levels at follow-up after adjustment for all covariates. Moreover, GAD was unrelated to several other inflammatory measures.
Individuals with GAD do not seem to exhibit chronic low-grade inflammation, suggesting different underlying biobehavioral mechanisms to those from other anxiety disorders. Low adiponectin levels may be linked to symptoms of GAD through brain areas directly involved in the processing of fear and anxiety.
Mots-clé
Generalized anxiety disorder, adiponectin, cardiovascular diseases, cohort study, inflammation, interleukin-6
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/04/2020 11:40
Dernière modification de la notice
11/07/2020 5:18
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