Frequency and determinants of using pharmacological enhancement in the clinical practice of in-hospital stroke rehabilitation.

Détails

ID Serval
serval:BIB_B13551550F0B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Frequency and determinants of using pharmacological enhancement in the clinical practice of in-hospital stroke rehabilitation.
Périodique
European Neurology
Auteur(s)
Engelter S.T., Urscheler N., Baronti F., Vuadens P., Koch J., Frank M., Disserens K., Jenni W.
ISSN
1421-9913 (Electronic)
ISSN-L
0014-3022
Statut éditorial
Publié
Date de publication
2012
Volume
68
Numéro
1
Pages
28-33
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Background: Pharmacological enhancement in stroke rehabilitation (PESR) is promising. Data about its use in clinical practice are missing. Methods: In a prospective, explorative study of four rehabilitation centers, we systematically observed the frequency and determinants of using PESR in consecutive patients. PESR was defined as using agents potentially enhancing post-stroke recovery exclusively to aid rehabilitation without an established indication. Results: 257 (55.4%) of 464 patients had agents potentially enhancing recovery. Selective serotonin reuptake inhibitors (SSRI) (n = 125, 26.9%), levodopa (n = 114, 24.6%), serotonin-noradrenaline reuptake inhibitors (SNRI) (n = 52, 11.2%), and acetylcholinesterase inhibitors (n = 48, 10.3%) were used most often. SSRI in 102/125 patients and SNRI in 46/52 patients were mostly used for accompanying depressive symptoms. 159 (34.3%) patients had PESR (without an otherwise established indication). In PESR patients, levodopa (n = 102, 64.1%) was used most commonly. PESR was primarily used for aphasia (36.5%) and paresis (25.2%). PESR patients did not differ from non-PESR patients in age, gender and stroke type. However, the utilization rates of PESR differed significantly across centers (2, 4, 38 and 55%). Conclusion: SSRI and SNRI were predominately used for accompanying depression, while levodopa was nearly exclusively used to aid stroke rehabilitation in the absence of an otherwise established indication. The differences in utilization rates for PESR between centers suggest therapeutic uncertainty and indicate the need for additional studies.
Pubmed
Web of science
Création de la notice
02/08/2012 18:12
Dernière modification de la notice
20/08/2019 15:20
Données d'usage