Inhibition of angiogenesis by non-steroidal anti-inflammatory drugs: from the bench to the bedside and back.

Détails

ID Serval
serval:BIB_B12DF2C4142B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Inhibition of angiogenesis by non-steroidal anti-inflammatory drugs: from the bench to the bedside and back.
Périodique
Current Drug Targets
Auteur⸱e⸱s
Monnier Y., Zaric J., Rüegg C.
ISSN
1389-4501
1568-010X
Statut éditorial
Publié
Date de publication
2005
Volume
4
Numéro
1
Pages
31-38
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Résumé
The formation of new blood vessels, a process globally referred to as angiogenesis, occurs in a number of pathological conditions, such as cancer and chronic inflammation. Recent findings indicate that cyclooxygenase-2 (COX-2), the inducible form of the cyclooxygenase (COX) isoenzymes, acts as a potent inducer of angiogenesis. Non-steroidal anti-inflammatory drugs (NSAIDs) are classical inhibitors of COX enzymes, which are widely prescribed for the treatment of inflammation, pain and fever. Selective COX-2 inhibitors (COXIBs) have been subsequently developed with the purpose to improve the safety profile of this class of therapeutics. More recently, substantial preclinical evidence demonstrated that NSAIDS and COXIBs have anti-angiogenic properties. This newly recognized activity opens the possibility of using these drugs for the treatment of angiogenesis-dependent diseases. In this article we review the most recent advances in understanding the mechanisms by which NSAIDs and COXIBs suppress angiogenesis, and we discuss their potential clinical use as anti-angiogenic drugs.
Mots-clé
Animals, Anti-Inflammatory Agents, Non-Steroidal, Blood Vessels, Cyclooxygenase Inhibitors, Humans, Neovascularization, Pathologic, Prostaglandin-Endoperoxide Synthases
Pubmed
Web of science
Création de la notice
28/01/2008 9:36
Dernière modification de la notice
20/08/2019 16:20
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