Long-term Metabolic and Socioeducational Outcomes of Transient Neonatal Diabetes: A Longitudinal and Cross-sectional Study.

Détails

ID Serval
serval:BIB_B128E834DF4C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Long-term Metabolic and Socioeducational Outcomes of Transient Neonatal Diabetes: A Longitudinal and Cross-sectional Study.
Périodique
Diabetes care
Auteur(s)
Le Bourgeois F., Beltrand J., Baz B., Julla J.B., Riveline J.P., Simon A., Flechtner I., Ait Djoudi M., Fauret-Amsellem A.L., Vial Y., Scharfmann R., Sommet J., Boudou P., Cavé H., Polak M. (co-dernier), Gautier J.F. (co-dernier), Busiah K. (co-dernier)
Collaborateur(s)
TNDM Long-Term Follow-Up Study Group
Contributeur(s)
Abu-Amara Olivieri S., Bachere N., Bellanne-Chantelot C., Bertrand A.M., Bourron O., De Boisvilliers F., Deumier B., Gourdy P., Hartemann A., Jellimann S., Le Tallec C., Martin-Dessilla A., Paoli A., Perrin M., Ribstein J., Saint-Martin C., Thivolet C., Vialettes B., Ythier H.
ISSN
1935-5548 (Electronic)
ISSN-L
0149-5992
Statut éditorial
Publié
Date de publication
06/2020
Peer-reviewed
Oui
Volume
43
Numéro
6
Pages
1191-1199
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Transient neonatal diabetes mellitus (TNDM) occurs during the 1st year of life and remits during childhood. We investigated glucose metabolism and socioeducational outcomes in adults.
We included 27 participants with a history of TNDM currently with (n = 24) or without (n = 3) relapse of diabetes and 16 non-TNDM relatives known to be carriers of causal genetic defects and currently with (n = 9) or without (n = 7) diabetes. Insulin sensitivity and secretion were assessed by hyperinsulinemic-euglycemic clamp and arginine-stimulation testing in a subset of 8 TNDM participants and 7 relatives carrying genetic abnormalities, with and without diabetes, compared with 17 unrelated control subjects without diabetes.
In TNDM participants, age at relapse correlated positively with age at puberty (P = 0.019). The mean insulin secretion rate and acute insulin response to arginine were significantly lower in TNDM participants and relatives of participants with diabetes than in control subjects (median 4.7 [interquartile range 3.7-5.7] vs. 13.4 [11.8-16.1] pmol/kg/min, P < 0.0001; and 84.4 [33.0-178.8] vs. 399.6 [222.9-514.9] µIU/mL, P = 0.0011), but were not different between participants without diabetes (12.7 [10.4-14.3] pmol/kg/min and 396.3 [303.3-559.3] µIU/mL, respectively) and control subjects. Socioeducational attainment was lower in TNDM participants than in the general population, regardless of diabetes duration.
Relapse of diabetes occurred earlier in TNDM participants compared with relatives and was associated with puberty. Both groups had decreased educational attainment, and those with diabetes had lower insulin secretion capacity; however, there was no difference in insulin resistance in adulthood. These forms of diabetes should be included in maturity-onset diabetes of the young testing panels, and relatives of TNDM patients should be screened for underlying defects, as they may be treated with drugs other than insulin.
Mots-clé
Internal Medicine, Endocrinology, Diabetes and Metabolism, Advanced and Specialised Nursing
Pubmed
Web of science
Création de la notice
25/04/2020 20:31
Dernière modification de la notice
06/11/2020 6:23
Données d'usage