Independent prognostic value of ploidy in colorectal cancer. A prospective study using image cytometry

Détails

ID Serval
serval:BIB_B11FB538B64A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Independent prognostic value of ploidy in colorectal cancer. A prospective study using image cytometry
Périodique
Cancer
Auteur(s)
Albe  X., Vassilakos  P., Helfer-Guarnori  K., Givel  J. C., de Quay  N., Suardet  L., Eliason  J. F., Odartchenko  N.
ISSN
0008-543X (Print)
Statut éditorial
Publié
Date de publication
09/1990
Volume
66
Numéro
6
Pages
1168-75
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep 15
Résumé
In a prospective study, the DNA content of Feulgen-stained nuclei obtained from fresh samples of 211 colorectal adenocarcinomas was evaluated by means of image analysis. The DNA histogram classification took into account aneuploidy and S-phase fraction for diploid cases. No significant relationship was found between ploidy and sex, age, preoperative carcinoembryonic antigen (CEA), size of the tumor, histologic differentiation, or Dukes' stage. Aneuploidy was more frequently encountered in distal tumors. Preoperative CEA, histologic differentiation, Dukes' stage, and ploidy were individually associated with overall survival. In Dukes' A, B, and C tumors, patients with normal and elevated CEA had no significant difference in overall survival. A relationship was apparent between disease-free survival and site, histologic differentiation, Dukes' stage, and ploidy. Multivariate overall survival analysis did not reveal independent prognostic significance of ploidy when all Dukes' stages were considered. In contrast, Dukes' stage, differentiation, and ploidy were good indicators of higher risk of colorectal cancer-related death in patients undergoing curative surgery. Dukes' stage and ploidy were also indicators for recurrence. Thus, routine histopathologic characteristics should be used in combination with quantitative cytologic features for the definition of a relevant prognostic index in colorectal cancer.
Mots-clé
Adenocarcinoma/analysis/*genetics/pathology Adult Aged Aged, 80 and over Carcinoembryonic Antigen/analysis Cell Nucleus/ultrastructure Colonic Neoplasms/analysis/*genetics/pathology DNA, Neoplasm/*analysis Female Flow Cytometry Humans Male Middle Aged Multivariate Analysis Neoplasm Staging *Ploidies Prognosis Prospective Studies Rectal Neoplasms/analysis/*genetics/pathology Survival Rate
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 8:56
Dernière modification de la notice
20/08/2019 15:20
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