The nature of in vivo mechanical signals that influence cartilage health and progression to knee osteoarthritis.

Détails

ID Serval
serval:BIB_B103C0ECF932
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The nature of in vivo mechanical signals that influence cartilage health and progression to knee osteoarthritis.
Périodique
Current Rheumatology Reports
Auteur(s)
Andriacchi T.P., Favre J.
ISSN
1534-6307 (Electronic)
ISSN-L
1523-3774
Statut éditorial
Publié
Date de publication
2014
Volume
16
Numéro
11
Pages
463
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Résumé
Knee osteoarthritis is a disease that can be initiated along multiple pathways that ultimately leads to pain, loss of function and breakdown of the articular cartilage. While the various pathways have biological and structural elements, the mechanical pathways play a critical role in the development of the disease. The forces and motions occurring during ambulation provide mechanical signals sensed at the scale of the cell that are critical to healthy joint homeostasis. As such, ambulatory changes associated with aging, obesity, or joint injury that occur prior to the development of symptoms of OA can ultimately lead to clinical OA. Conversely, inter-scale signaling (e.g., pain) generated by biological changes in the early stages of OA can produce adaptive ambulatory changes that can modify the rate of OA progression. Thus, the nature of the physical and clinical response to the mechanical signals that occur during ambulation is critical to understanding the etiology of osteoarthritis.
Pubmed
Web of science
Création de la notice
02/12/2014 18:01
Dernière modification de la notice
20/08/2019 15:20
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