Sex differences in urinary levels of several biological indicators of exposure: a human volunteer study

Détails

Ressource 1Télécharger: BIB_B0D40188FBF0.P001.pdf (315.91 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_B0D40188FBF0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sex differences in urinary levels of several biological indicators of exposure: a human volunteer study
Périodique
Toxicology Letters
Auteur(s)
Tomicic Catherine, Berode Michèle, Oppliger Anne, Castella Vincent, Leyvraz Fabienne, Praz-Christinaz Sophie Maria, Danuser Brigitta
ISSN
1879-3169 (Electronic)
ISSN-L
0378-4274
Statut éditorial
Publié
Date de publication
10/05/2011
Peer-reviewed
Oui
Volume
202
Numéro
3
Pages
218-225
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The aim of the study was to quantify the variability on biological indicators of exposure between men and women for three well known solvents: methyl ethyl ketone, 1-methoxy-2-propanol and 1,1,1-trichloroethane. Another purpose was to explore the effect of selected CYP2E1 polymorphisms on the toxicokinetic profile. Controlled human exposures were carried out in a 12 m³ exposure chamber for each solvent separately, during 6h and at half of the threshold limit value. The human volunteers groups were composed of ten young men and fifteen young women, including ten women using hormonal contraceptive. An analysis of variance mainly showed an effect on the urinary levels of several biomarkers of exposure among women due to the use of hormonal contraceptive, with an increase of more than 50% in metabolites concentrations and a decrease of up to 50% in unchanged substances concentrations, suggesting an increase in their metabolism rate. The results also showed a difference due to the genotype CYP2E1*6, when exposed to methyl ethyl ketone, with a tendency to increase CYP2E1 activity when volunteers were carriers of the mutant allele. Our study suggests that not only physiological differences between men and women but also differences due to sex hormones levels can have an impact on urinary concentrations of several biomarkers of exposure. The observed variability due to sex among biological exposure indices can lead to misinterpretation of biomonitoring results. This aspect should have its place in the approaches for setting limits of occupational exposure.

Mots-clé
Adult, Biomarkers/urine, Butanones/pharmacokinetics, Butanones/urine, Contraceptives, Oral, Hormonal/metabolism, Cytochrome P-450 CYP2E1/classification, Cytochrome P-450 CYP2E1/genetics, Environmental Exposure, Environmental Monitoring, Female, Genotype, Humans, Male, Occupational Diseases/etiology, Occupational Diseases/metabolism, Occupational Diseases/physiopathology, Polymorphism, Genetic, Propylene Glycols/pharmacokinetics, Propylene Glycols/urine, Sex Factors, Solvents/metabolism, Solvents/pharmacokinetics, Surveys and Questionnaires, Trichloroethanes/pharmacokinetics, Trichloroethanes/urine, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/03/2011 15:20
Dernière modification de la notice
20/08/2019 15:19
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