Early atherosclerosis in childhood type 1 diabetes: role of raised systolic blood pressure in the absence of dyslipidaemia.

Détails

ID Serval
serval:BIB_B0CA0716316B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Early atherosclerosis in childhood type 1 diabetes: role of raised systolic blood pressure in the absence of dyslipidaemia.
Périodique
European Journal of Pediatrics
Auteur(s)
Schwab K.O., Doerfer J., Krebs A., Krebs K., Schorb E., Hallermann K., Superti-Furga A., Zieger B., März W., Schmidt-Trucksäss A., Winkler K.
ISSN
0340-6199 (Print)
ISSN-L
0340-6199
Statut éditorial
Publié
Date de publication
2007
Volume
166
Numéro
6
Pages
541-548
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article
Résumé
The intentions of our investigation were (1) to search for atherogenic risk factors and signs of incipient atherosclerosis in children and adolescents with type 1 diabetes (T1DM) in comparison to well-matched control subjects, (2) to evaluate risk factor associations with carotid intima media thickness (cIMT) in diabetic patients and control subjects, and (3) to acquire a better knowledge of early atherogenesis in children and adolescents with and without T1DM. 94 diabetic children (age median 12.3 years, HbA1c median 7.7%) and 40 non-diabetic controls (age median 12.3 years) were investigated. Mean cIMT was determined using high-resolution B-mode ultrasound with an automated contour identification procedure. Compared to controls, subjects with diabetes had significantly elevated cIMT (p = 0.041) and systolic BP (p = 0.007) but showed a less atherogenic lipid profile. Most markers of inflammation, endothelial function and fibrinolytic activity were higher in diabetic subjects than in controls. Multiple linear regression analysis revealed a significant relationship (r = 0.53, p = 0.036) between bilateral mean cIMT and diverse risk factors in patients with T1DM. Spearman rank correlation showed that diabetes duration (rho = 0.32, p = 0.029), systolic BP (rho = 0.32, p = 0.004), weight (rho = 0.257, p = 0.022), and height (rho = 0.265, p = 0.018) significantly correlated with bilateral mean cIMT in the 94 diabetic patients. In conclusion, in well-controlled type 1 diabetic children systolic BP may be of greater importance than dyslipidaemia in early atherogenesis. BMI, markers of sustained inflammation, endothelial dysfunction and fibrinolytic activity are increased in diabetic versus non-diabetic children but none of them correlates significantly with cIMT. Their prognostic value remains to be determined.
Mots-clé
Adolescent, Atherosclerosis/etiology, Biological Markers, Carotid Arteries/pathology, Carotid Arteries/ultrasonography, Child, Diabetes Mellitus, Type 1/complications, Dyslipidemias/complications, Female, Humans, Hypertension/complications, Linear Models, Male, Risk Factors, Tunica Intima/pathology, Tunica Intima/ultrasonography
Pubmed
Web of science
Création de la notice
14/03/2011 16:09
Dernière modification de la notice
20/08/2019 15:19
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