GLUT2 is a high affinity glucosamine transporter.

Détails

ID Serval
serval:BIB_B0AD1F7C5CB6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
GLUT2 is a high affinity glucosamine transporter.
Périodique
FEBS letters
Auteur⸱e⸱s
Uldry M., Ibberson M., Hosokawa M., Thorens B.
ISSN
0014-5793
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
524
Numéro
1-3
Pages
199-203
Langue
anglais
Résumé
When expressed in Xenopus oocytes, GLUT1, 2 and 4 transport glucosamine with V(max) values that are three- to four-fold lower than for glucose. The K(m)s for glucosamine and glucose of GLUT1 and GLUT4 were similar. In contrast, GLUT2 had a much higher apparent affinity for glucosamine than for glucose (K(m)=0.8+/-0.1 mM vs. approximately 17-20 mM). Glucosamine transport by GLUT2 was confirmed in mammalian cells and, using hepatocytes from control or GLUT2-null mice, HgCl(2)-inhibitable glucosamine uptake by liver was shown to be exclusively through GLUT2. These data have implications for glucosamine effects on impaired glucose metabolism and for structure-function studies of transporter sugar binding sites.
Mots-clé
Animals, Biological Transport, Cell Line, Glucosamine, Glucose Transporter Type 2, Hepatocytes, Humans, Mice, Mice, Knockout, Monosaccharide Transport Proteins, Oocytes, Transfection, Xenopus
Pubmed
Web of science
Création de la notice
24/01/2008 13:41
Dernière modification de la notice
20/08/2019 15:19
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