Signaling Pathways Governing the Caspofungin Paradoxical Effect in Aspergillus fumigatus.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_B08B776E274F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Lettre (letter): communication adressée à l'éditeur.
Collection
Publications
Institution
Titre
Signaling Pathways Governing the Caspofungin Paradoxical Effect in Aspergillus fumigatus.
Périodique
mBio
Auteur⸱e⸱s
Papon N., Morio F., Sanglard D.
ISSN
2150-7511 (Electronic)
Statut éditorial
Publié
Date de publication
18/08/2020
Peer-reviewed
Oui
Volume
11
Numéro
4
Pages
e01816-20
Langue
anglais
Notes
Publication types: Journal Article ; Comment
Publication Status: epublish
Résumé
Aspergillus fumigatus is responsible for a wide range of diseases affecting several million people worldwide. Currently, a few families of antifungals are available to fight aspergillosis, and we are facing a worrisome increase in resistance to azoles, the drugs used for both first-line treatment and prophylaxis of invasive aspergillosis. In this context, some of the latest antifungals, i.e., echinocandins, have gained attention. Even though acquired resistance to echinocandins is yet uncommon in A. fumigatus clinical isolates, some strains exhibit another characteristic that relies on their capacity to grow at suprainhibitory echinocandin concentrations in vitro This intriguing phenomenon, especially observed with caspofungin and now referred to as the caspofungin paradoxical effect (CPE), relies on molecular mechanisms that were hitherto little understood. Here, we discuss the recent key findings of Valero and colleagues published in mBio (C. Valero, A. C. Colabardini, J. Chiaratto, L. Pardeshi, et al., mBio 11:e00816-20, 2020, https://doi.org/10.1128/mBio.00816-20) that will allow a better understanding of the complex regulatory pathway involved in governing the response of A. fumigatus to caspofungin.
Mots-clé
Antifungal Agents, Aspergillus fumigatus, Caspofungin, Echinocandins, Fungal Proteins, Transcription Factors, Aspergillus fumigatus, caspofungin, paradoxical growth, tolerance, transcription factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/09/2020 10:57
Dernière modification de la notice
30/04/2021 6:13
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