Paternal age and sporadic schizophrenia : evidence for de novo mutations

Détails

ID Serval
serval:BIB_B05833331EA2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Paternal age and sporadic schizophrenia : evidence for de novo mutations
Périodique
American journal of medical genetics
Auteur⸱e⸱s
Malaspina D., Corcoran C., Fahim C., Berman A., Harkavy-Friedman J., Yale S., Goetz D., Goetz R., Harlap S., Gorman J.
ISSN
0148-7299
Statut éditorial
Publié
Date de publication
2002
Volume
114
Numéro
3
Pages
299-303
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S. - Publication Status: ppublish
Résumé
Schizophrenia is an etiologically heterogeneous syndrome. It has a strong genetic component and exists in clinically indistinguishable familial and nonfamilial (sporadic) forms. A significant role for de novo genetic mutations in genetic schizophrenia vulnerability is suggested by a strong monotonic increase in schizophrenia risk with advancing paternal age. However, an alternative explanation for the paternal age effect in schizophrenia is that childbearing is delayed in fathers who themselves have genetic schizophrenia vulnerability. In this study, we compared paternal birth ages between patient groups with familial (n = 35) and sporadic (n = 68) patients with DSM-IV schizophrenia from an inpatient schizophrenia research unit. If later age of fathering children is related to having some genetic schizophrenia vulnerability, then paternal birth age should be later in familial schizophrenia cases than in sporadic cases, and any association of father's age and schizophrenia risk in offspring would be a spurious finding, unrelated to etiology. However, if de novo mutations cause sporadic schizophrenia, then patients without a family history of schizophrenia would have older fathers than familial patients. We found that patients without a family history of schizophrenia had significantly older fathers (4.7 years) than familial patients; so later childbirth was not attributable to parental psychiatric illness. These findings support the hypothesis that de novo mutations contribute to the risk for sporadic schizophrenia.
Mots-clé
Age Factors, Analysis of Variance, Family Health, Female, Humans, Male, Maternal Age, Paternal Age, Risk Factors, Schizophrenia / etiology, Schizophrenia / genetics
Pubmed
Création de la notice
24/06/2009 14:43
Dernière modification de la notice
20/08/2019 16:19
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