A simple mathematical model for the functional peptide/MHC/TCR interactions

Détails

ID Serval
serval:BIB_B034A57BB749
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A simple mathematical model for the functional peptide/MHC/TCR interactions
Périodique
Journal of Immunology
Auteur⸱e⸱s
Eberl  G., Roggero  M. A., Corradin  G.
ISSN
0022-1767 (Print)
Statut éditorial
Publié
Date de publication
01/1995
Volume
154
Numéro
1
Pages
219-25
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan 1
Résumé
T cell-specific activation requires ligation of TCRs with peptide-MHC complexes on the APC. On the basis of simple chemical and statistical laws, we have constructed a mathematical model to describe this trimolecular interaction between effector and target cells, and we demonstrate its predictive value in the case of in vitro peptide Ag titration. Moreover, this model can generate mechanistic explanations for cellular immunity phenomena like anergy, peripheral tolerance, cell-mediated suppression, TCR antagonism, and thymic selection events.
Mots-clé
Amino Acid Sequence Animals Antigen-Presenting Cells/immunology/*metabolism Antigens/immunology/*metabolism H-2 Antigens/immunology/*metabolism HLA-C Antigens/immunology Humans Lymphocyte Activation Macromolecular Substances Mast-Cell Sarcoma Mice Mice, Inbred BALB C Mice, Inbred DBA *Models, Biological Molecular Sequence Data Peptide Fragments/immunology/*metabolism Protein Binding Receptors, Antigen, T-Cell/immunology/*metabolism T-Lymphocytes, Cytotoxic/immunology/*metabolism Tumor Cells, Cultured
Pubmed
Web of science
Création de la notice
24/01/2008 14:55
Dernière modification de la notice
20/08/2019 15:19
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