Improved segmentation of deep brain grey matter structures using magnetization transfer (MT) parameter maps.
Détails
ID Serval
serval:BIB_AFCF028C8BE7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Improved segmentation of deep brain grey matter structures using magnetization transfer (MT) parameter maps.
Périodique
NeuroImage
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
01/08/2009
Peer-reviewed
Oui
Volume
47
Numéro
1
Pages
194-198
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Basal ganglia and brain stem nuclei are involved in the pathophysiology of various neurological and neuropsychiatric disorders. Currently available structural T1-weighted (T1w) magnetic resonance images do not provide sufficient contrast for reliable automated segmentation of various subcortical grey matter structures. We use a novel, semi-quantitative magnetization transfer (MT) imaging protocol that overcomes limitations in T1w images, which are mainly due to their sensitivity to the high iron content in subcortical grey matter. We demonstrate improved automated segmentation of putamen, pallidum, pulvinar and substantia nigra using MT images. A comparison with segmentation of high-quality T1w images was performed in 49 healthy subjects. Our results show that MT maps are highly suitable for automated segmentation, and so for multi-subject morphometric studies with a focus on subcortical structures.
Mots-clé
Adolescent, Adult, Aged, Aged, 80 and over, Brain/anatomy & histology, Electronic Data Processing, Female, Globus Pallidus/anatomy & histology, Humans, Magnetic Resonance Imaging/methods, Male, Middle Aged, Nerve Fibers, Myelinated, Probability, Putamen/anatomy & histology, Substantia Nigra/anatomy & histology, Thalamus/anatomy & histology, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/01/2010 14:08
Dernière modification de la notice
18/12/2023 14:00