The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion

Détails

ID Serval
serval:BIB_AF86673237F1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion
Périodique
Cell Death and Differentiation
Auteur⸱e⸱s
Munding  C., Keller  M., Niklaus  G., Papin  S., Tschopp  J., Werner  S., Beer  H. D.
ISSN
1350-9047 (Print)
Statut éditorial
Publié
Date de publication
11/2006
Volume
13
Numéro
11
Pages
1938-49
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
The estrogen-responsive B box protein (EBBP) and Pyrin belong to a family of structurally related proteins. While mutations in the pyrin gene cause an autoinflammatory disease, the biological function of EBBP is unknown. In this study, we identified the proinflammatory cytokine interleukin-1beta (IL-1beta) as an EBBP-binding partner. Furthermore, caspase-1 and NACHT, LRR and Pyrin domain containing protein (NALP) 1, two components of the recently identified inflammasome, a platform for the activation of caspase-1, also interact with EBBP. These proteins bind to the RFP domain of EBBP, suggesting that this domain of so far unknown function is an important protein-binding domain. EBBP was secreted in a caspase-1-dependent manner from cultured cells, and its secretion was enhanced by IL-1beta. Vice versa, endogenous and overerexpressed EBBP increased IL-1beta secretion. These results provide evidence for a role of EBBP in innate immunity by enhancing the alternative secretion pathway of IL-1beta.
Mots-clé
Adaptor Proteins, Signal Transducing/metabolism Animals Apoptosis Regulatory Proteins/metabolism COS Cells Caspase 1/metabolism Cercopithecus aethiops Cytoskeletal Proteins/metabolism DNA-Binding Proteins/*metabolism Estrogens/pharmacology Humans Interleukin-1beta/*secretion Protein Binding Protein Precursors/metabolism Protein Structure, Tertiary Transcription Factors/*metabolism Transfection
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:18
Dernière modification de la notice
20/08/2019 15:19
Données d'usage