Growth of Infants Fed Formula with Evolving  Nutrition Composition: A Single-Arm Non-Inferiority Study.

Détails

Ressource 1Télécharger: nutrients-09-00219-v2.pdf (1122.51 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_AF841536C284
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Growth of Infants Fed Formula with Evolving  Nutrition Composition: A Single-Arm Non-Inferiority Study.
Périodique
Nutrients
Auteur⸱e⸱s
Spalinger J., Nydegger A., Belli D., Furlano R.I., Yan J., Tanguy J., Pecquet S., Destaillats F., Egli D., Steenhout P.
ISSN
2072-6643 (Electronic)
ISSN-L
2072-6643
Statut éditorial
Publié
Date de publication
01/03/2017
Peer-reviewed
Oui
Volume
9
Numéro
3
Pages
E219
Langue
anglais
Notes
Publication types: Clinical Trial ; Comparative Study ; Journal Article ; Multicenter Study
Publication Status: epublish
Résumé
The nutritional composition of human milk evolves over the course of lactation, to match the changing needs of infants. This single-arm, non-inferiority study evaluated growth against the WHO standards in the first year of life, in infants consecutively fed four age-based formulas with compositions tailored to infants' nutritional needs during the 1st, 2nd, 3rd-6th, and 7th-12th months of age. Healthy full-term formula-fed infants (n = 32) were enrolled at ≤14 days of age and exclusively fed study formulas from enrollment, to the age of four months. Powdered study formulas were provided in single-serving capsules that were reconstituted using a dedicated automated preparation system, to ensure precise, hygienic preparation. The primary outcome was the weight-for-age z-score (WAZ) at the age of four months (vs. non-inferiority margin of -0.5 SD). Mean (95% CI) z-scores for the WAZ (0.12 (-0.15, 0.39)), as well as for the length-for-age (0.05 (-0.19, 0.30)), weight-for-length (0.16 (-0.16, 0.48)), BMI-for-age (0.11 (-0.20, 0.43)), and head circumferencefor-age (0.41 (0.16, 0.65)) at the age of four months, were non-inferior. Throughout the study, anthropometric z-scores tracked closely against the WHO standards (within ±1 SD). In sum, a fourstage, age-based infant formula system with nutritional compositions tailored to infants' evolving needs, supports healthy growth consistent with WHO standards, for the first year of life.

Mots-clé
Body Height/ethnology, Body Mass Index, Child Development, Cohort Studies, Female, Follow-Up Studies, Growth Charts, Head, Humans, Infant Formula/adverse effects, Infant, Newborn, Lost to Follow-Up, Male, Nutritive Value, Overweight/epidemiology, Overweight/ethnology, Overweight/etiology, Patient Dropouts/ethnology, Pediatric Obesity/epidemiology, Pediatric Obesity/ethnology, Pediatric Obesity/etiology, Risk Factors, Switzerland/epidemiology, Urban Health/ethnology, Weight Gain/ethnology, World Health Organization, human milk,  WHO growth standard,  evolving nutritional composition,  infant formula,  personalized nutrition,  protein,  staged‐formula  delivery system
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/03/2017 11:37
Dernière modification de la notice
20/08/2019 15:19
Données d'usage