Defining and searching for structural motifs using DeepView/Swiss-PdbViewer.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_AF7C5749A380
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Defining and searching for structural motifs using DeepView/Swiss-PdbViewer.
Périodique
BMC Bioinformatics
Auteur⸱e⸱s
Johansson M.U., Zoete V., Michielin O., Guex N.
ISSN
1471-2105 (Electronic)
ISSN-L
1471-2105
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
13
Pages
173
Langue
anglais
Résumé
BACKGROUND: Today, recognition and classification of sequence motifs and protein folds is a mature field, thanks to the availability of numerous comprehensive and easy to use software packages and web-based services. Recognition of structural motifs, by comparison, is less well developed and much less frequently used, possibly due to a lack of easily accessible and easy to use software.
RESULTS: In this paper, we describe an extension of DeepView/Swiss-PdbViewer through which structural motifs may be defined and searched for in large protein structure databases, and we show that common structural motifs involved in stabilizing protein folds are present in evolutionarily and structurally unrelated proteins, also in deeply buried locations which are not obviously related to protein function.
CONCLUSIONS: The possibility to define custom motifs and search for their occurrence in other proteins permits the identification of recurrent arrangements of residues that could have structural implications. The possibility to do so without having to maintain a complex software/hardware installation on site brings this technology to experts and non-experts alike.
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/01/2013 15:56
Dernière modification de la notice
30/04/2021 6:13
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