Natural history of growth hormone deficiency in a pediatric cohort.

Détails

ID Serval
serval:BIB_AF2E8B8BC454
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Natural history of growth hormone deficiency in a pediatric cohort.
Périodique
Hormone Research In Pædiatrics
Auteur(s)
Deillon E., Hauschild M., Faouzi M., Stoppa-Vaucher S., Elowe-Gruau E., Dwyer A., Theintz G.E., Dubuis J.M., Mullis P.E., Pitteloud N., Phan-Hug F.
ISSN
1663-2826 (Electronic)
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
83
Numéro
4
Pages
252-261
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
BACKGROUND/AIMS: Controversies still exist regarding the evaluation of growth hormone deficiency (GHD) in childhood at the end of growth. The aim of this study was to describe the natural history of GHD in a pediatric cohort.
METHODS: This is a retrospective study of a cohort of pediatric patients with GHD. Cases of acquired GHD were excluded. Univariate logistic regression was used to identify predictors of GHD persisting into adulthood.
RESULTS: Among 63 identified patients, 47 (75%) had partial GHD at diagnosis, while 16 (25%) had complete GHD, including 5 with multiple pituitary hormone deficiencies. At final height, 50 patients underwent repeat stimulation testing; 28 (56%) recovered and 22 (44%) remained growth hormone (GH) deficient. Predictors of persisting GHD were: complete GHD at diagnosis (OR 10.1, 95% CI 2.4-42.1), pituitary stalk defect or ectopic pituitary gland on magnetic resonance imaging (OR 6.5, 95% CI 1.1-37.1), greater height gain during GH treatment (OR 1.8, 95% CI 1.0-3.3), and IGF-1 level <-2 standard deviation scores (SDS) following treatment cessation (OR 19.3, 95% CI 3.6-103.1). In the multivariate analysis, only IGF-1 level <-2 SDS (OR 13.3, 95% CI 2.3-77.3) and complete GHD (OR 6.3, 95% CI 1.2-32.8) were associated with the outcome.
CONCLUSION: At final height, 56% of adolescents with GHD had recovered. Complete GHD at diagnosis, low IGF-1 levels following retesting, and pituitary malformation were strong predictors of persistence of GHD. © 2015 S. Karger AG, Basel.
Pubmed
Web of science
Création de la notice
12/06/2015 17:52
Dernière modification de la notice
20/08/2019 16:18
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