The Clinical Course of Venous Thromboembolism May Differ According to Cancer Site.
Détails
ID Serval
serval:BIB_AECE4D25C507
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The Clinical Course of Venous Thromboembolism May Differ According to Cancer Site.
Périodique
The American journal of medicine
Collaborateur⸱rice⸱s
RIETE investigators
Contributeur⸱rice⸱s
Aibar M.A., Arcelus J.I., Ballaz A., Barba R., Barrón M., Barrón-Andrés B., Bascuñana J., Blanco-Molina A., Bueso T., Casado I., Culla A., de Miguel J., Del Toro J., Díaz-Peromingo J.A., Falgá C., Fernández-Capitán C., Font C., Font L., Gallego P., García-Bragado F., García-Brotons P., Gómez V., González J., Grau E., Grimón A., Guirado L., Gutiérrez J., Hernández G., Hernández-Blasco L., Isern V., Jara-Palomares L., Jaras M.J., Jiménez D., Lacruz B., Lecumberri R., Lobo J.L., López-Jiménez L., López-Reyes R., López-Sáez J.B., Lorente M.A., Lorenzo A., Madridano O., Marchena P.J., Martín-Antorán J.M., Martín-Martos F., Monreal M., Morales M.V., Nauffal D., Nieto J.A., Nieto S., Núñez M.J., Otalora S., Otero R., Pagán B., Pedrajas J.M., Pérez C., Pérez G., Peris M.L., Porras J.A., Ramírez L., Reig O., Riera A., Rivas A., Rodríguez-Dávila M.A., Rosa V., Ruiz-Artacho P., Ruiz-Giménez N., Ruiz-Martínez C., Sampériz A., Sala C., Sanz O., Soler S., Sopeña B., Suarez I., Suriñach J.M., Tiberio G., Tolosa C., Trujillo-Santos J., Uresandi F., Valle R., Vela J., Villalta J., Malfante P.C., Verhamme P., Wells P., Hirmerova J., Malý R., Tomko T., Salgado E., Bertoletti L., Bura-Riviere A., Farge-Bancel D., Hij A., Mahé I., Merah A., Papadakis M., Braester A., Brenner B., Tzoran I., Apollonio A., Barillari G., Candeloro G., Ciammaichella M., Di Micco P., Ferrazzi P., Grandone E., Lessiani G., Lodigiani C., Mastroiacovo D., Pace F., Pinelli M., Prandoni P., Rota L., Tiraferri E., Tufano A., Visonà A., Belovs A., Skride A., Moreira M., Ribeiro J.L., Sousa M.S., Bosevski M., Zdraveska M., Alatri A., Bounameaux H., Calanca L., Mazzolai L., Serrano J.C., Decousus H., Reis A.
ISSN
1555-7162 (Electronic)
ISSN-L
0002-9343
Statut éditorial
Publié
Date de publication
03/2017
Peer-reviewed
Oui
Volume
130
Numéro
3
Pages
337-347
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
We hypothesized that the clinical course of venous thromboembolism in patients with active cancer may differ according to the specificities of primary tumor site.
We used data from RIETE (international registry of patients with venous thromboembolism) to compare the clinical venous thromboembolism-related outcomes during the course of anticoagulation in patients with one of the 4 more frequent cancers (breast, prostate, colorectal, or lung cancer).
As of September 2014, 3947 cancer patients were recruited, of whom 938 had breast, 629 prostate, 1189 colorectal, and 1191 lung cancer. Overall, 55% had metastatic disease (42%, 36%, 53%, and 72%, respectively). During the course of anticoagulant therapy (mean duration, 139 days), the rate of thromboembolic recurrences was similar to the rate of major bleeding in patients with breast (5.6 [95% confidence interval (CI), 3.8-8.1] vs 4.1 [95% CI, 2.7-5.9] events per 100 patient-years) or colorectal cancer (10 [95% CI, 7.6-13] vs 12 [95% CI, 9.4-15] per 100 patient-years). In contrast, in patients with prostate cancer, the rate of venous thromboembolic recurrences was half the rate of major bleeding (6.9 [95% CI, 4.4-10] vs 13 [95% CI, 9.2-17] events per 100 patient-years), whereas in those with lung cancer, the rate of thromboembolic recurrences was twofold higher than the rate of major bleeding (27 [95% CI, 22-23] vs 11 [95% CI, 8.6-15] per 100 patient-years).
Significant differences in the clinical profile of venous thromboembolic-related outcomes were observed according to the site of cancer. These findings suggest the development of cancer-specific anticoagulant strategies as an area for further research.
We used data from RIETE (international registry of patients with venous thromboembolism) to compare the clinical venous thromboembolism-related outcomes during the course of anticoagulation in patients with one of the 4 more frequent cancers (breast, prostate, colorectal, or lung cancer).
As of September 2014, 3947 cancer patients were recruited, of whom 938 had breast, 629 prostate, 1189 colorectal, and 1191 lung cancer. Overall, 55% had metastatic disease (42%, 36%, 53%, and 72%, respectively). During the course of anticoagulant therapy (mean duration, 139 days), the rate of thromboembolic recurrences was similar to the rate of major bleeding in patients with breast (5.6 [95% confidence interval (CI), 3.8-8.1] vs 4.1 [95% CI, 2.7-5.9] events per 100 patient-years) or colorectal cancer (10 [95% CI, 7.6-13] vs 12 [95% CI, 9.4-15] per 100 patient-years). In contrast, in patients with prostate cancer, the rate of venous thromboembolic recurrences was half the rate of major bleeding (6.9 [95% CI, 4.4-10] vs 13 [95% CI, 9.2-17] events per 100 patient-years), whereas in those with lung cancer, the rate of thromboembolic recurrences was twofold higher than the rate of major bleeding (27 [95% CI, 22-23] vs 11 [95% CI, 8.6-15] per 100 patient-years).
Significant differences in the clinical profile of venous thromboembolic-related outcomes were observed according to the site of cancer. These findings suggest the development of cancer-specific anticoagulant strategies as an area for further research.
Pubmed
Création de la notice
14/02/2017 11:47
Dernière modification de la notice
20/08/2019 15:18
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