Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase.

Détails

ID Serval
serval:BIB_AE8EAAC69CD7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase.
Périodique
Cancer Investigation
Auteur⸱e⸱s
Juillerat-Jeanneret L., Bernasconi C.C., Bricod C., Gros S., Trepey S., Benhattar J., Janzer R.C.
ISSN
1532-4192[electronic]
Statut éditorial
Publié
Date de publication
2008
Volume
26
Numéro
6
Pages
597-609
Langue
anglais
Résumé
The DNA repair and detoxifying enzymes, O(6)-methylguanine-DNA-methyltransferase (MGMT) and glutathione-S-transferase (GST), may be responsible fpr poor response to alkylating agents in glioblastoma treatment. The methylation of MGMT promoter and the expression of MGMT and GST were highly heterogeneous in surgical specimens of human glioblastoma and in established human glioblastoma cells under 2-D and 3-D culture conditions, suggesting an intrinsic property of these cells. MGMT and GST expression did not predict the sensitivity of glioblastoma cells to alkylating agents. Combination of alkylating agents with inhibitors of GST disclosed additive effects, suggesting that inhibition of GST should be considered in glioblastoma therapy.
Mots-clé
Alkylating Agents, Brain Neoplasms, Carmustine, Cell Line, Tumor, Cell Proliferation, DNA Methylation, DNA Modification Methylases, DNA Repair Enzymes, DNA Replication, Dose-Response Relationship, Drug, Enzyme Inhibitors, Ethacrynic Acid, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Glioblastoma, Glutathione S-Transferase pi, Glutathione Transferase, Guanine, Humans, Melphalan, Promoter Regions, Genetic, Tumor Suppressor Proteins
Pubmed
Web of science
Création de la notice
11/07/2008 11:09
Dernière modification de la notice
20/08/2019 15:18
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