Efficacious treatment of non-dermatophyte mould onychomycosis with topical amphotericin B.

Détails

ID Serval
serval:BIB_AE65943F7AD7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Efficacious treatment of non-dermatophyte mould onychomycosis with topical amphotericin B.
Périodique
Dermatology
Auteur(s)
Lurati M., Baudraz-Rosselet F., Vernez M., Spring P., Bontems O., Fratti M., Monod M.
ISSN
1421-9832 (Electronic)
ISSN-L
1018-8665
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
223
Numéro
4
Pages
289-292
Langue
anglais
Notes
Publication types: Journal Article
Résumé
BACKGROUND: Dermatophytes are the main cause of onychomycosis, but various non-dermatophyte moulds (NDMs) are often the infectious agents in abnormal nails. In particular, Fusarium spp. and other NDMs are mostly insensitive to standard onychomycosis treatment with topical agents as well as with oral terbinafine and itraconazole.¦OBJECTIVE: The aim of this work is to report the efficacy of a topical amphotericin B solution on NDM onychomycosis in a series of 8 patients resistant to multiple conventional topical and systemic treatments.¦METHODS: Treatment consisted in the application of an optimized amphotericin B solution once daily to the affected nails and surrounding tissue. No mechanical debridement or medications were allowed except for trimming excessively long nails or in some cases occasionally applying urea-based cream to soften thickened nail plates.¦RESULTS: Onychomycosis was clinically cured in all patients after a 12-month treatment. Mycological cure was obtained in all but 1 patient.¦CONCLUSIONS: Topical amphotericin B is an efficacious, safe, cheap and easy-to-apply treatment which should be considered as first-line therapy for NDM onychomycosis.
Pubmed
Web of science
Création de la notice
28/04/2012 13:24
Dernière modification de la notice
20/08/2019 16:18
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