A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth.

Détails

Ressource 1Télécharger: BIB_AE4FD8521BCE.P001.pdf (270.49 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_AE4FD8521BCE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth.
Périodique
Journal of Experimental Medicine
Auteur(s)
Rennert P., Schneider P., Cachero T.G., Thompson J., Trabach L., Hertig S., Holler N., Qian F., Mullen C., Strauch K., Browning J.L., Ambrose C., Tschopp J.
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
2000
Volume
192
Numéro
11
Pages
1677-1684
Langue
anglais
Résumé
A proliferation-inducing ligand (APRIL) is a ligand of the tumor necrosis factor (TNF) family that stimulates tumor cell growth in vitro and in vivo. Expression of APRIL is highly upregulated in many tumors including colon and prostate carcinomas. Here we identify B cell maturation antigen (BCMA) and transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI), two predicted members of the TNF receptor family, as receptors for APRIL. APRIL binds BCMA with higher affinity than TACI. A soluble form of BCMA, which inhibits the proliferative activity of APRIL in vitro, decreases tumor cell proliferation in nude mice. Growth of HT29 colon carcinoma cells is blocked when mice are treated once per week with the soluble receptor. These results suggest an important role for APRIL in tumorigenesis and point towards a novel anticancer strategy.
Mots-clé
3T3 Cells, Adaptor Proteins, Signal Transducing, Animals, B-Cell Activating Factor, B-Cell Maturation Antigen, B-Lymphocytes/physiology, Carrier Proteins/metabolism, Cell Division, Cell Line, Transformed, Cell Transformation, Neoplastic, HT29 Cells, Humans, Membrane Proteins/genetics, Membrane Proteins/metabolism, Mice, Mice, Nude, Neoplasms/therapy, Receptors, Tumor Necrosis Factor/genetics, Receptors, Tumor Necrosis Factor/metabolism, Recombinant Fusion Proteins/genetics, Recombinant Fusion Proteins/metabolism, Solubility, Transmembrane Activator and CAML Interactor Protein, Tumor Cells, Cultured, Tumor Necrosis Factor Ligand Superfamily Member 13, Tumor Necrosis Factor-alpha/genetics, Tumor Necrosis Factor-alpha/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:18
Dernière modification de la notice
20/08/2019 15:18
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