1H NMR detection of vitamin C in human brain in vivo.

Détails

ID Serval
serval:BIB_AE2E0A508026
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
1H NMR detection of vitamin C in human brain in vivo.
Périodique
Magnetic Resonance in Medicine
Auteur(s)
Terpstra M., Gruetter R.
ISSN
0740-3194 (Print)
ISSN-L
0740-3194
Statut éditorial
Publié
Date de publication
2004
Volume
51
Numéro
2
Pages
225-229
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Résumé
Vitamin C (ascorbate) is well established as an essential nutrient that functions as an antioxidant. Since it is present in the human brain at detectable concentrations, this study was designed to detect and quantify ascorbate in the human brain in vivo using 1H NMR spectroscopy (MRS). Ascorbate was consistently detected in all five study subjects, and was measured using MEGA-PRESS difference editing. The in vivo resonance pattern was consistent with that of ascorbate based on position, line width, peak pattern, and relative intensity. Metabolites with a potential for coediting were assessed using phantom solutions. The putative resonances of myo-inositol, lactate, glycerophosphocholine, phosphocholine, and phosphoethanolamine were detected at positions distinct from those of ascorbate. This study represents the first in vivo detection of vitamin C in the human brain using 1H MRS. A concentration of 1.3 +/- 0.3 micromol/g (mean +/- SD, N = 4) was estimated.
Mots-clé
Adult, Ascorbic Acid/metabolism, Brain/metabolism, Female, Humans, Magnetic Resonance Spectroscopy/methods, Male
Pubmed
Web of science
Création de la notice
04/08/2010 16:28
Dernière modification de la notice
20/08/2019 16:17
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